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	Provedor de dados BJMBR (1) Autor Hongfang,W. (1) Jianmin,Z. (1) Meifu,F. (1) Palavra-chave Drug resistance (1) Epirubicin (1) Hepatocellular carcinoma (1) Microcarrier (1) Spheroids (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2002 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Resistance of multicellular aggregates to pharmorubicin observed in human hepatocarcinoma cells BJMBR Jianmin,Z.; Hongfang,W.; Meifu,F.. The objective of the present study was to investigate the multicellular resistance of human hepatocarcinoma cells BEL-7402 to pharmorubicin. Cells (1 x 10(4)) and 200 microcarrier Cytodex-3 beads were seeded onto a 24-well plate and cultured in RPMI 1640 medium. After the formation of multicellular aggregates, morphology and cell viability were analyzed by scanning electron microscopy, transmission electron microscopy and flow cytometry, respectively. The IC50 was determined by flow cytometry and MTT assay after the cells cultured in aggregates and monolayers were treated with pharmorubicin. The culture products exhibited structural characteristics somewhat similar to those of trabecular hepatocarcinoma in vivo. Among the microcarriers, cells were... Tipo: Info:eu-repo/semantics/article Palavras-chave: Hepatocellular carcinoma; Spheroids; Drug resistance; Microcarrier; Epirubicin. Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000200015 Registros recuperados: 1 Primeira ... 1 ... Última

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