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| Melo,Marcelia Garcez Dória de; Araújo,Adriano Antunes de Souza; Serafini,Mairim Russo; Carvalho,Larissa Feitosa; Bezerra,Marília Santos; Ramos,Cledison Santos; Bonjardim,Leonardo Rigoldi; Albuquerque-Júnior,Ricardo Luiz Cavalcanti; Lima,Julianeli Tolentino; Siqueira,Rosana Souza; Fortes,Vanessa Silveira; Fonseca,Maria José Vieira; Quintans-Júnior,Lucindo José. |
| Atranorin (ATR) is the main compound from the lichen Cladina kalbii Ahti, which grows in the arid regions of northeastern Brazil. This study was conducted to evaluate the anti-inflammatory and toxicological properties of ATR. To evaluate anti-inflammatory properties, paw edema was induced by injecting 0.1 mL of carrageenan into the subplantar region of the right hind paw of rats, and leukocyte migration was induced by injection of 500 µL of carrageenan into the peritoneal cavity of mice. In addition, we determined ATR cytotoxicity in L929 cells by MTT assay and acute (5 g/kg-single dose) and subchronic (50 mg/kg-30 days) toxicity tests in Wistar rats. The results showed that ATR (100 mg/kg and 200 mg/kg) exhibited significant anti-inflammatory activity... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cladina kalbii/pharmacognosy; Atranorin/anti-inflamatory activity; Atranorin/toxicity; Medicinal plants. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000400024 |
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