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	Provedor de dados BJMBR (3) Autor Menéndez,R. (3) Más,R. (3) Arruzazabala,M.L. (2) Carbajal,D. (2) Molina,V. (2) Noa,M. (2) Valdés,S. (2) Amor,A.M. (1) Fraga,V. (1) González,R.M. (1) Jiménez,S. (1) Mais... Palavra-chave Policosanol (2) Atherosclerotic lesions (1) Cerebral ischemia (1) D002 (1) Exogenous hypercholesterolemia (1) Gerbils (1) Higher aliphatic alcohols (1) Lipids (1) Microsomes (1) Peroxidation (1) Rabbits (1) Reperfusion brain edema (1) Mais... Tipo do documento Info:eu-repo/semantics/article (3) Ano 2000 (2) 1999 (1) País Brazil (3) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Effect of policosanol on cerebral ischemia in Mongolian gerbils BJMBR Molina,V.; Arruzazabala,M.L.; Carbajal,D.; Valdés,S.; Noa,M.; Más,R.; Fraga,V.; Menéndez,R.. Policosanol is a mixture of higher aliphatic primary alcohols isolated from sugar cane wax, whose main component is octacosanol. An inhibitory effect of policosanol on platelet aggregation and cerebral ischemia in animal models has been reported. Thus, the objective of the present study was to evaluate the effect of policosanol on cerebral ischemia induced by unilateral carotid ligation and bilateral clamping and recirculation in Mongolian gerbils. Policosanol (200 mg/kg) administered immediately after unilateral carotid ligation and at 12- or 24-h intervals for 48 h significantly inhibited mortality and clinical symptoms when compared with controls, whereas lower doses (100 mg/kg) were not effective. Control animals showed swelling (tissue vacuolization)... Tipo: Info:eu-repo/semantics/article Palavras-chave: Cerebral ischemia; Gerbils; Policosanol; Reperfusion brain edema. Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999001000014 Inhibition of rat microsomal lipid peroxidation by the oral administration of D002 BJMBR Menéndez,R.; Amor,A.M.; González,R.M.; Jiménez,S.; Más,R.. The effect of D002, a defined mixture of higher primary alcohols purified from bee wax, on in vivo and in vitro lipid peroxidation was studied. The extent of lipid peroxidation was measured on the basis of the levels of thiobarbituric acid reactive substances (TBARS). When D002 (5-100 mg/kg body weight) was administered orally to rats for two weeks, a partial inhibition of the in vitro enzymatic and non-enzymatic lipid peroxidation was observed in liver and brain microsomes. Maximal protection (46%) occurred at a dose of 25 mg/kg. D002 behaved differently depending on both the presence of NADPH and the integrity of liver microsomes, which suggests that under conditions where microsomal metabolism was favored the protective effect of D002 was increased.... Tipo: Info:eu-repo/semantics/article Palavras-chave: D002; Higher aliphatic alcohols; Microsomes; Lipids; Peroxidation. Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000100012 Protective effect of policosanol on atherosclerotic lesions in rabbits with exogenous hypercholesterolemia BJMBR Arruzazabala,M.L.; Noa,M.; Menéndez,R.; Más,R.; Carbajal,D.; Valdés,S.; Molina,V.. Policosanol is a mixture of higher aliphatic alcohols purified from sugar cane wax, with cholesterol-lowering effects demonstrable in experimental models and in patients with type II hypercholesterolemia. The protective effects of policosanol on atherosclerotic lesions experimentally induced by lipofundin in rabbits and rats and spontaneously developed in stumptail monkeys have been described. The present study was conducted to determine whether policosanol administered orally to rabbits with exogenous hypercholesterolemia also protects against the development of atherosclerotic lesions. Male New Zealand rabbits weighing 1.5 to 2 kg were randomly divided into three experimental groups which received 25 or 200 mg/kg policosanol (N = 7) orally for 60 days... Tipo: Info:eu-repo/semantics/article Palavras-chave: Policosanol; Atherosclerotic lesions; Exogenous hypercholesterolemia; Rabbits. Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000700015 Registros recuperados: 3 Primeira ... 1 ... Última

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