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Typical and atypical enteropathogenic Escherichia coli bacterial translocation associated with tissue hypoperfusion in rats 56
Liberatore,A.M.A.; Moreira,F.C.; Gomes,T.A.T.; Menchaca-Diaz,J.L.; Koh,I.H.J..
Although enteropathogenic Escherichia coli (EPEC) are well-recognized diarrheal agents, their ability to translocate and cause extraintestinal alterations is not known. We investigated whether a typical EPEC (tEPEC) and an atypical EPEC (aEPEC) strain translocate and cause microcirculation injury under conditions of intestinal bacterial overgrowth. Bacterial translocation (BT) was induced in female Wistar-EPM rats (200-250 g) by oroduodenal catheterization and inoculation of 10 mL 10(10) colony forming unit (CFU)/mL, with the bacteria being confined between the duodenum and ileum with ligatures. After 2 h, mesenteric lymph nodes (MLN), liver and spleen were cultured for translocated bacteria and BT-related microcirculation changes were monitored in...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Enteropathogenic Escherichia coli (EPEC); Atypical EPEC; Bacterial translocation; Microcirculation; Tissue perfusion.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011001000007
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