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	Provedor de dados BJMBR (5) Autor Mendez-Otero,R. (5) Santiago,M.F. (3) Bittencourt-Navarrete,R.E. (1) Bittencourt-Navarrete,R.E. de (1) Freitas,G.R. de (1) Giraldi-Guimarães,A. (1) Gubert,F. (1) Hedin-Pereira,C. (1) Miyakoshi,L.M. (1) Nascimento,I.C.do (1) Zaverucha-do-Valle,C. (1) Mais... Palavra-chave 9-O-acetyl GD3 (2) Development (2) Gangliosides (2) Nitric oxide synthase (2) Superior colliculus (2) 9-O-acetylated gangliosides (1) Adult neurogenesis (1) Migration (1) NMDA receptor (1) Neural stem cells (1) Neurite outgrowth (1) Neuronal migration (1) Postsynaptic density targeting (1) Retinotectal projection (1) Rostral migratory stream (1) Subventricular zone (1) Mais... Tipo do documento Info:eu-repo/semantics/article (4) Info:eu-repo/semantics/other (1) Ano 2009 (1) 2005 (1) 2004 (1) 2003 (1) 2001 (1) País Brazil (5) Idioma Inglês (5)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 5 Primeira ... 1 ... Última NMDA receptor blockade alters the intracellular distribution of neuronal nitric oxide synthase in the superficial layers of the rat superior colliculus BJMBR Bittencourt-Navarrete,R.E. de; Nascimento,I.C.do; Santiago,M.F.; Mendez-Otero,R.. Nitric oxide (NO) is a molecular messenger involved in several events of synaptic plasticity in the central nervous system. Ca2+ influx through the N-methyl-D-aspartate receptor (NMDAR) triggers the synthesis of NO by activating the enzyme neuronal nitric oxide synthase (nNOS) in postsynaptic densities. Therefore, NMDAR and nNOS are part of the intricate scenario of postsynaptic densities. In the present study, we hypothesized that the intracellular distribution of nNOS in the neurons of superior colliculus (SC) superficial layers is an NMDAR activity-dependent process. We used osmotic minipumps to promote chronic blockade of the receptors with the pharmacological agent MK-801 in the SC of 7 adult rats. The effective blockade of NMDAR was assessed by... Tipo: Info:eu-repo/semantics/article Palavras-chave: Superior colliculus; Nitric oxide synthase; NMDA receptor; Postsynaptic density targeting. Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000200007 The 9-O-acetyl GD3 gangliosides are expressed by migrating chains of subventricular zone neurons in vitro BJMBR Miyakoshi,L.M.; Mendez-Otero,R.; Hedin-Pereira,C.. Neurons from the anterior subventricular zone (SVZ) of the cerebral cortex migrate tangentially to become interneurons in the olfactory bulb during development and in adult rodents. This migration was defined as neuronophilic, independent of a radial glial substrate. The cortical SVZ and the rostral migratory stream to the olfactory bulb were shown to be rich in 9-O-acetyl GD3 gangliosides (9-O-acGD3), which have been previously shown to be implicated in gliophilic migration in the rodent cerebral cortex and cerebellum. In the present study, we performed SVZ explant cultures using rats during their first postnatal week to analyze the expression of these gangliosides in chain migration of neuronal precursors. We characterized migrating chains of these... Tipo: Info:eu-repo/semantics/other Palavras-chave: Subventricular zone; Migration; 9-O-acetylated gangliosides; Rostral migratory stream. Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000500016 Expression of neuronal nitric oxide synthase in the developing superficial layers of the rat superior colliculus BJMBR Giraldi-Guimarães,A.; Bittencourt-Navarrete,R.E.; Mendez-Otero,R.. We investigated the level of expression of neuronal nitric oxide synthase (nNOS) in the retinorecipient layers of the rat superior colliculus during early postnatal development. Male and female Lister rats ranging in age between the day of birth (P0) and the fourth postnatal week were used in the present study. Two biochemical methods were used, i.e., in vitro measurement of NOS specific activity by the conversion of [³H]-arginine to [³H]-citrulline, and analysis of Western blotting immunoreactive bands from superior colliculus homogenates. As revealed by Western blotting, very weak immunoreactive bands were observed as early as P0-2, and their intensity increased progressively at least until P21. The analysis of specific activity of NOS showed similar... Tipo: Info:eu-repo/semantics/article Palavras-chave: Superior colliculus; Nitric oxide synthase; Development; Retinotectal projection. Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000600013 Regulation and function of neurogenesis in the adult vertebrate brain BJMBR Mendez-Otero,R.; Zaverucha-do-Valle,C.; Gubert,F.; Freitas,G.R. de; Santiago,M.F.. Most adult tissues retain a reservoir of self-renewing, multipotent stem cells that can generate differentiated tissue components. Until recently, the brain was thought to be an exception to this rule and for many years the pervasive dogma of neurobiology relegated neurogenesis to the embryonic and earlier postnatal stages of development. The discovery of constant neuronal replacement in the adult brain has changed the way we think about neurological diseases and about the exploration of new strategies for brain repair. In this review we will explore the potential of adult neural stem cells and we will present some of our own work on this subject. We will also discuss the possibility that adult neurogenesis and neuronal replacement may also play a role in... Tipo: Info:eu-repo/semantics/article Palavras-chave: Neural stem cells; Adult neurogenesis; 9-O-acetyl GD3; Gangliosides. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005001000012 Functional role of a specific ganglioside in neuronal migration and neurite outgrowth BJMBR Mendez-Otero,R.; Santiago,M.F.. Cell migration occurs extensively during mammalian brain development and persists in a few regions in the adult brain. Defective migratory behavior of neurons is thought to be the underlying cause of several congenital disorders. Knowledge of the dynamics and molecular mechanisms of neuronal movement could expand our understanding of the normal development of the nervous system as well as help decipher the pathogenesis of neurological developmental disorders. In our studies we have identified and characterized a specific ganglioside (9-O-acetyl GD3) localized to the membrane of neurons and glial cells that is expressed in regions of cell migration and neurite outgrowth in the developing and adult rat nervous system. In the present article we review our... Tipo: Info:eu-repo/semantics/article Palavras-chave: Neuronal migration; Gangliosides; Development; 9-O-acetyl GD3; Neurite outgrowth. Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000800006 Registros recuperados: 5 Primeira ... 1 ... Última

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