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	Provedor de dados BJMBR (1) Autor Azeredo-Coutinho,R.B.G. (1) Matos,D.C.S. (1) Mendonça,S.C.F. (1) Nery,J.A.C. (1) Valete-Rosalino,C.M. (1) Palavra-chave Interferon-gamma (1) Interleukin-10 (1) Leishmania braziliensis (1) Lepromatous leprosy (1) Mucocutaneous leishmaniasis (1) Mycobacterium leprae (1) Mais... Tipo do documento Info:eu-repo/semantics/other (1) Ano 2012 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Interleukin-10-dependent down-regulation of interferon-gamma response to Leishmania by Mycobacterium leprae antigens during the clinical course of a coinfection BJMBR Azeredo-Coutinho,R.B.G.; Matos,D.C.S.; Nery,J.A.C.; Valete-Rosalino,C.M.; Mendonça,S.C.F.. We have described a case of a patient with an intriguing association of mucocutaneous leishmaniasis with lepromatous leprosy, two opposite polar forms of these spectral diseases. In the present follow-up study, we investigated the effect of the addition of Mycobacterium leprae antigens on interferon-gamma (IFN-γ) production in Leishmania antigen-stimulated cultures of peripheral blood mononuclear cells (PBMC) from this patient. For this purpose, PBMC cultures were stimulated with crude L. braziliensis and/or M. leprae whole-cell antigen extracts or with concanavalin A. In some experiments, neutralizing anti-human interleukin (IL)-10 antibodies were added to the cultures. IFN-γ and IL-10 levels in culture supernatants were measured by ELISA. During active... Tipo: Info:eu-repo/semantics/other Palavras-chave: Interferon-gamma; Interleukin-10; Mucocutaneous leishmaniasis; Lepromatous leprosy; Leishmania braziliensis; Mycobacterium leprae. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000700010 Registros recuperados: 1 Primeira ... 1 ... Última

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