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Endogenous opiate analgesia induced by tonic immobility in guinea pigs BJMBR
Leite-Panissi,C.R.A.; Rodrigues,C.L.; Brentegani,M.R.; Menescal-de-Oliveira,L..
A function of the endogenous analgesic system is to prevent recuperative behaviors generated by tissue damage, thus preventing the emission of species-specific defensive behaviors. Activation of intrinsic nociception is fundamental for the maintenance of the behavioral strategy adopted. Tonic immobility (TI) is an inborn defensive behavior characterized by a temporary state of profound and reversible motor inhibition elicited by some forms of physical restraint. We studied the effect of TI behavior on nociception produced by the formalin and hot-plate tests in guinea pigs. The induction of TI produced a significant decrease in the number of flinches (18 ± 6 and 2 ± 1 in phases 1 and 2) and lickings (6 ± 2 and 1 ± 1 in phases 1 and 2) in the formalin test...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Tonic immobility; Guinea pig; Antinociception; Opioids; Naloxone; Analgesia.
Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000200013
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Cholinergic-opioidergic interaction in the central amygdala induces antinociception in the guinea pig BJMBR
Leite-Panissi,C.R.A.; Brentegani,M.R.; Menescal-de-Oliveira,L..
Several studies have demonstrated the involvement of the central nucleus of the amygdala (CEA) in the modulation of defensive behavior and in antinociceptive regulation. In a previous study, we demonstrated the existence of a cholinergic-opioidergic interaction in the CEA, modulating the defensive response of tonic immobility in guinea pigs. In the present study, we investigated a similar interaction in the CEA, but now involved in the regulation of the nociceptive response. Microinjection of carbachol (2.7 nmol) and morphine (2.2 nmol) into the CEA promoted antinociception up to 45 min after microinjection in guinea pigs as determined by a decrease in the vocalization index in the vocalization test. This test consists of the application of a peripheral...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Antinociception; Vocalization test; Cholinergic-opioidergic interaction; Amygdala; Naloxone; Atropine.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004001000018
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