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| Peralta-Leal,Valeria; Leal-Ugarte,Evelia; Meza-Espinoza,Juan P.; Dávalos-Rodríguez,Ingrid P.; Bocanegra-Alonso,Anabel; Acosta-González,Rosa I.; Gonzales,Enrique; Nair,Saraswathy; Durán-González,Jorge. |
| The serotonergic system has been hypothesized to contribute to the biological susceptibility to type 2 diabetes mellitus (T2DM) and body-mass index (BMI) categories. We investigate a possible association of 5-HTTLPR polymorphism (L and S alleles) in the promoter region of the serotonin transporter gene (SLC6A4) with the development of T2DM and/or higher BMI by analyzing a sample of 138 individuals diagnosed with T2DM and 172 unrelated controls from the Mexican general population. In the total sample genotypes were distributed according to Hardy- Weinberg equilibrium, and S allele frequency was 0.58. There was no statistical association between 5-HTTLPR polymorphism and the development of T2DM in this Mexican population sample (p = 0.12). Nevertheless,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: SLC6A4 gene; 5-HTTLPR polymorphism; Type 2 diabetes mellitus; Body mass index. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572012000400007 |
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