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| Moreira,Juliana Junqueira; Coelho,Joyce Martins; Machado,Thais Sodré Lima; Morais,Ana Paula Lopes; Michelacci,Yara Maria; Baccarin,Raquel Yvonne Arantes. |
| ABSTRACT: Several studies, mainly in vitro, have shown that chondroitin sulfate (CS) and glucosamine (GlcN) do have chondro protective and anti-inflammatory actions. The aim of the present study was to investigate whether oral CS/GlcN supplementation has effects on the CS, hyaluronic acid (HA) and prostaglandin E2 (PGE2) concentrations on synovial fluid of equine osteoarthritic joints. Horses with mild osteoarthritis (OA) in tibiotarsal joint received daily PO doses of CS and GlcN (2.8/3.1 g) for 25 days. Synovial fluid (SF) and urine samples were collected before treatment (day 0), and every 7 days, until day 55 (30 days after the end of treatment). Urinary CS increased upon oral treatment, indicating that this compound was systemically distributed.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Chondroitin sulfate; Horse; Glucosamine; Osteoarthritis; Synovial fluid. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782019000900602 |
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