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	Provedor de dados BJMBR (2) Autor Krieger,J.E. (2) Miyakawa,A.A. (2) Junqueira,M.L. (1) Laurindo,F.R.M. (1) Oliveira,E.M. (1) Pereira,A.C. (1) Pertrini,C.M. (1) Xavier-Neto,J. (1) Mais... Palavra-chave Angiotensin converting enzyme (1) Angiotensin-I converting enzyme (1) CAMP (1) Cyclic AMP responsive element (1) Endothelial cells (1) Endothelium (1) Nitric oxide (1) Shear stress (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Info:eu-repo/semantics/other (1) Ano 2004 (1) 2003 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Control of the rat angiotensin I converting enzyme gene by CRE-like sequences BJMBR Xavier-Neto,J.; Pereira,A.C.; Oliveira,E.M.; Miyakawa,A.A.; Junqueira,M.L.; Krieger,J.E.. We characterized the role of potential cAMP-responsive elements (CRE) in basal and in induced angiotensin converting enzyme (ACE) gene promoter activity in order to shed light on the regulation of somatic ACE expression. We identified stimulators and repressors of basal expression between 122 and 288 bp and between 415 and 1303 bp upstream from the transcription start site, respectively, using a rabbit endothelial cell (REC) line. These regions also contained elements associated with the response to 8BrcAMP. When screening for CRE motifs we found pCRE, a proximal sequence between 209 and 222 bp. dCRE, a distal tandem of two CRE-like sequences conserved between rats, mice and humans, was detected between 834 and 846 bp. Gel retardation analysis of nuclear... Tipo: Info:eu-repo/semantics/article Palavras-chave: Angiotensin converting enzyme; Endothelium; CAMP; Cyclic AMP responsive element. Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004001000002 Nitric oxide regulates angiotensin-I converting enzyme under static conditions but not under shear stress BJMBR Pertrini,C.M.; Miyakawa,A.A.; Laurindo,F.R.M.; Krieger,J.E.. Mechanical forces including pressure and shear stress play an important role in vascular homeostasis via the control of the production and release of a variety of vasoactive factors. An increase in vascular shear stress is accompanied by nitric oxide (NO) release and NO synthase activation. Previously, we have demonstrated that shear stress induces angiotensin-I converting enzyme (ACE) down-regulation in vivo and in vitro. In the present study, we determined whether NO participates in the shear stress-induced ACE suppression response. Rabbit aortic endothelial cells were evaluated using the NO synthase inhibitor L-NAME, and two NO donors, diethylamine NONOate (DEA/NO) and sodium nitroprusside (SNP). Under static conditions, incubation of endothelial cells... Tipo: Info:eu-repo/semantics/other Palavras-chave: Shear stress; Angiotensin-I converting enzyme; Nitric oxide; Endothelial cells. Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000900005 Registros recuperados: 2 Primeira ... 1 ... Última

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