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	Provedor de dados BJMBR (2) Autor Montero-Lomelí,M. (2) Conceição,T.M. (1) Da Poian,A.T. (1) Galvão,D. (1) Morais,B.B. (1) Nardi,A.E. (1) Ramírez,J. (1) Santoro,A.B.M. (1) Villas-Bôas,C.S.A. (1) Mais... Palavra-chave Bipolar disorder (1) Carbamazepine (1) Dengue virus (1) Flavivirus (1) Lithium (1) Phosphoglucomutase (1) Protein synthesis (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2009 (1) 2007 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Dengue virus-induced regulation of the host cell translational machinery BJMBR Villas-Bôas,C.S.A.; Conceição,T.M.; Ramírez,J.; Santoro,A.B.M.; Da Poian,A.T.; Montero-Lomelí,M.. Dengue virus (DV)-induced changes in the host cell protein synthesis machinery are not well understood. We investigated the transcriptional changes related to initiation of protein synthesis. The human hepatoma cell line, HepG2, was infected with DV serotype 2 for 1 h at a multiplicity of infection of one. RNA was extracted after 6, 24 and 48 h. Microarray results showed that 36.5% of the translation factors related to initiation of protein synthesis had significant differential expression (Z-score ≥ ±2.0). Confirmation was obtained by quantitative real-time reverse transcription-PCR. Of the genes involved in the activation of mRNA for cap-dependent translation (eIF4 factors), eIF4A, eIF4G1 and eIF4B were up-regulated while the negative regulator of... Tipo: Info:eu-repo/semantics/article Palavras-chave: Dengue virus; Flavivirus; Protein synthesis. Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009001100004 Erythrocyte phosphoglucomutase activity of bipolar I patients currently using lithium or carbamazepine BJMBR Montero-Lomelí,M.; Galvão,D.; Morais,B.B.; Nardi,A.E.. Lithium has been used for the last five decades to treat bipolar disorder, but the molecular basis of its therapeutic effect is unknown. Phosphoglucomutase is a key enzyme in the metabolism of glycogen. In yeast, rabbit and human HEK293 cells, it is inhibited by lithium in the therapeutic concentration range. We measured the phosphoglucomutase activity in erythrocytes and the inhibitor constant for lithium in a population of healthy subjects and compared them to those of bipolar patients treated with lithium or carbamazepine. The specific activity of phosphoglucomutase measured in vitro in erythrocytes from control subjects presented a normal distribution, with the difference between the lowest and the highest activity being approximately 2-fold (0.53-1.10... Tipo: Info:eu-repo/semantics/article Palavras-chave: Phosphoglucomutase; Lithium; Carbamazepine; Bipolar disorder. Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000100003 Registros recuperados: 2 Primeira ... 1 ... Última

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