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| Bastos,Leandro Francisco Silva; Vago,Juliana Priscila; Caux,Thaís Rolla; Costa,Bruna Lopes; Godin,Adriana Martins; Menezes,Raquel Rezende; Pena,Roberta Ribas; Silva-Cunha,Armando; Sousa,Lirlândia Pires; Machado,Renes Resende; Moraes,Márcio Flávio Dutra; Fialho,Sílvia Ligório; Coelho,Márcio Matos. |
| Neuroimmune interactions underlying the development of pain sensitization in models of neuropathic pain have been widely studied. In this study, we evaluated the development of allodynia and its reduction associated with peripheral antineuroinflammatory effects induced by a dexamethasone-loaded biodegradable implant. Chronic constriction injury (CCI) of the sciatic nerve was performed in Wistar rats. The electronic von Frey test was applied to assess mechanical allodynia. The dexamethasone-loaded implant was placed perineurally at the moment of CCI or 12 days after surgery. Dorsal root ganglia (DRG; L4-L5) were harvested and nuclear extracts were assayed by Western blot for detection of nuclear factor (NF)-κB p65/RelA translocation. Dexamethasone delivered... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Chronic Constriction Injury; Dexamethasone/ pharmacology; Delivery device; Neuropathic Pain/ chemically induced; Nuclear Factor kappa B/ drug effects; Neuralgia/ chemically induced; NF-kappa B/ drug effects; Sciatic Nerve/ injuries; Absorbable Implants/ trends. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100591 |
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