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| Bonfanti,Gabriela; Bitencourt,Paula Eliete Rodrigues; Bona,Karine Santos De; Peroza,Luis Ricardo; Cargnelutti,Lariane Oliveira; Borges,Raphaela Maleski; Pigatto,Aline Grohe Schirmer; Fachinetto,Roselei; Boligon,Aline Augusti; Athayde,Margareth Linde; Gonçalves,Thissiane de Lima; Moretto,Maria Beatriz. |
| ABSTRACT Solanum guaraniticum is a medicinal plant traditionally used to treat gastric and liver diseases. However, there is no documented evidence corroborating its safety. The present study evaluated the potential toxicity of S. guaraniticum leaf extract after acute administration in rats. Single doses of the extract (1.250, 2.500, and 5.000 mg/kg) were administered by gavage, and the rats were then monitored for 48 h and/or 14 days. Mortality, acute signs of toxicity, and general activity in the open field test were assessed as well as hematological and biochemical parameters, enzymatic activity (δ-aminolevulinate dehydratase and acetylcholinesterase), and oxidative stress parameters (lipid peroxidation level, non-protein thiol content, tissue catalase... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Solanum guaraniticum/leaf extract/toxicity; Solanum guaraniticum/phytochemistry; Medicinal plants; Solanaceae. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000100006 |
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