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Choice of sterilizing/disinfecting agent: determination of the Decimal ReductionTime (D-Value) BJPS
Mazzola,Priscila Gava; Jozala,Angela Faustino; Novaes,Letícia Célia de Lencastre; Moriel,Patricia; Penna,Thereza Christina Vessoni.
Efforts to diminish the transmission of infections include programs in which disinfectants play a crucial role. Hospital surfaces and medical devices are potential sources of cross contamination, and each instrument, surface or area in a health care unit can be responsible for spread of infection. The decimal reduction time was used to study and compare the behavior of selected strains of microorganisms. The highest D-values for various bacteria were obtained for the following solutions: (i) 0.1% sodium dichloroisocyanurate (pH 7.0) - E. coli and A. calcoaceticus (D = 5.9 min); (ii) sodium hypochlorite (pH 7.0) at 0.025% for B. stearothermophilus (D = 24 min), E. coli and E. cloacae (D = 7.5 min); at 0.05% for B. stearothermophilus (D = 9.4 min) and E....
Tipo: Info:eu-repo/semantics/article Palavras-chave: Disinfection; Disinfectant agents; Decimal reduction time/determination.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000400013
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Minimal inhibitory concentration (MIC) determination of disinfectant and/or sterilizing agents BJPS
Mazzola,Priscila Gava; Jozala,Angela Faustino; Novaes,Letícia Célia de Lencastre; Moriel,Patricia; Penna,Thereza Christina Vessoni.
Due to the growing number of outbreaks of infection in hospital and nurseries, it becomes essential to set up a sanitation program that indicates that the appropriate chemical agent was chosen for application in the most effective way. Validating the effectiveness of decontamination and disinfection is an important and often challenging task. In order to study and compare the behavior of selected microorganisms, they were submitted to minimal inhibitory concentration (MIC). The MIC intervals, which reduced bacteria populations over 6 log10, were: 59 to 156 mg/L of quaternary ammonium compounds (QACs); 63 to 10000 mg/L of chlorhexidine; 1375 to 3250 mg/L of glutaraldehyde; 39 to 246 mg/L of formaldehyde; 43750 to 87500 mg/L of ethanol; 1250 to 6250 mg/L of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Minimal inhibitory concentration; Disinfectant agents; Sterilizing agents; Sanitation/programs.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000200008
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Cholesterol oxides inhibit cholesterol esterification by lecithin: cholesterol acyl transferase BJPS
Pincinato,Eder de Carvalho; Moriel,Patricia; Abdalla,Dulcinéia Saes Parra.
Cholesterol oxides are atherogenic and can affect the activity of diverse important enzymes for the lipidic metabolism. The effect of 7β-hydroxycholesterol, 7-ketocholesterol, 25-hydroxycholesterol, cholestan-3β,5α,6β-triol,5,6β-epoxycholesterol, 5,6α-epoxycholesterol and 7α-hydroxycholesterol on esterification of cholesterol by lecithin:cholesterol acyl transferase (LCAT, EC 2.3.1.43) and the transfer of esters of cholesterol oxides from high density lipoprotein (HDL) to low density lipoproteins (LDL) and very low density lipoproteins (VLDL) by cholesteryl ester transfer protein (CETP) was investigated. HDL enriched with increasing concentrations of cholesterol oxides was incubated with fresh plasma as source of LCAT. Cholesterol and cholesterol oxides...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cholesterol/oxides; Cholesterol/acyl transferase; Lecithin; Protein/cholesteryl ester transfer; Lipoprotein/high density; Cholesterol/reverse transport.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000300007
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