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An antithrombin-dependent sulfated polysaccharide isolated from the green alga Caulerpa cupressoides has in vivo anti- and prothrombotic effects Ciência Rural
Rodrigues,José Ariévilo Gurgel; Queiroz,Ismael Nilo Lino de; Quinderé,Ana Luíza Gomes; Vairo,Bruno Cunha; Mourão,Paulo Antônio de Souza; Benevides,Norma Maria Barros.
Red algae sulfated polysaccharides (SPs) have been widely described as anticoagulant and antithrombotic agents; however no description of antithrombotic activity regarding green algae SPs has been reported. Caulerpa cupressoides (Chlorophyta) has three different SPs fractions (SP1, SP2 and SP3). We investigated the effects of SP2 on thrombin activity by antithrombin and in an experimental model of venous thrombosis in rats. The inhibition of thrombin assay was evaluated using antithrombin (AT) in the presence of SP2 and the antithrombotic activity was investigated in rats with thromboplastin as the thrombogenic stimulus. The anticoagulant effects of SP2 are suggested be due to the potentiation of thrombin inhibition by antithrombin (IC50 ~ 10.0µg mL-1) and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Green alga; Sulfated polymers; Biological events; Coagulation system; Thrombosis.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782011000400014
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