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| Brandstetter,Luciana Ramos Gaston; Araújo,Eugênio Gonçalves de; Moreno,Juan Carlos Duque; Fioravanti,Maria Clorinda Soares; Moura,Veridiana Maria Brianezi Dignani de; Machado,Patrícia de Almeida. |
| The effects of topical and intraluminal Carolina Rinse Solution (CRS) in p44/42 (ERK 1/2) and p38 MAPK activation profile, in rabbit jejunum after ischemia and reperfusion (I/R), were investigated in this study. Fifteen New Zealand rabbits were allocated in three groups: Sham-operated (A), Ischemia and reperfusion (B) and CRS (C). Groups B and C were subjected to one hour of ischemia and two hours of reperfusion. In group C, ten minutes prior to reperfusion, the bowel lumen was filled with CRS, and the segment was immersed in CRS until reperfusion onset. Ischemia and reperfusion stimulated the phosphorylation of the p44/42 MAPK and p38 MAPK pathways in some layers of jejunum. Progressive activation of p44/42 MAPK was chiefly localized in the crypts of... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: ERK 1/2; Intestine; Ischemia; P38; Reperfusion. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782014000100014 |
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| Gonçalves,Bárbara Hess Rodrigues; Matos,Bruna Dantas; Faleiro,Mariana Batista Rodrigues; Arnhold,Emmanuel; Matos,Moema Pacheco Chediak; Santin,Ana Paula Iglesias; Moura,Veridiana Maria Brianezi Dignani de. |
| ABSTRACT: In this study the correlation between the clinical score, mast cell count and interleukin 31 (IL-31) immunostaining in the skin of dogs with atopic dermatitis was determined. A total of 31 dogs of different breeds, from one to eight years of age, were chosen for the study. The 20 females and 11 males were categorized based on the CADESI-4 system, as having discrete, moderate or marked atopic dermatitis. Skin samples were collected from the axillary and interdigital regions and stained with hematoxylin and eosin for cytohistomorphological analyses and toluidine blue to evaluate the mast cell counts, and immunohistochemistry for the IL-31 immunostaining. Animals revealing higher atopic dermatitis scores had greater numbers of mast cells and IL-31... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Canine allergy; Pro-inflammatory cytokine; Toluidine blue. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782018000900600 |
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| Miguel,Marina Pacheco; Sales,Tatyane Penha; Menezes,Liliana Borges de; Moraes,Júlia Miranda; Moura,Veridiana Maria Brianezi Dignani de; Brito,Luiz Augusto Batista; Araújo,Eugênio Gonçalves de. |
| As neoplasias mamárias são as mais frequentes em cadelas, representando 25 a 30% do total das afecções neoplásicas das fêmeas caninas. Durante a carcinogênese ocorrem várias modificações na expressão de proteínas, como a Cyr61, envolvida na proliferação celular e na angiogênese. Assim, este estudo teve por objetivo determinar o perfil de expressão dessa proteína, por meio da técnica de imunoistoquímica, em glândulas mamárias normais e neoplásicas de cadelas. Para tal, foram selecionados 10 casos de cada um dos diagnósticos: adenoma simples, carcinoma complexo e carcinoma simples sólido, além de 10 fragmentos de glândulas mamárias normais, perfazendo o total de 40 fragmentos. O anticorpo policlonal anti-Cyr61 apresentou marcação em células epiteliais... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Canino; Neoplasias mamárias; Imunoistoquímica; CCN1. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782010000600020 |
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| Lima,Caroline Rocha de Oliveira; Rabelo,Rogério Elias; Vulcani,Valcinir Aloísio Scalla; Cardoso,Lorena Damasio; Sousa,Nicaelle Luan de Moura; Moura,Veridiana Maria Brianezi Dignani de. |
| The p53 gene encodes a protein that has molecular weight of 53kD and is also called p53 protein, being constantly studied for its classic concept of "genome guardian". This gene plays a range of essential functions to ensure the cell cycle control, in addition to playing a central role in carcinogenesis. With respect to neoplasias, it prevents the neoplastic transformation through three intricate mechanisms. Depending on the extent of the mutation, different responses may be sent by p53 and those range since the disruption of the cell cycle, the correction of the mutation through the activation of repair proteins or still, the induction of senescence or cell death by apoptosis. This review aims to address the structural and functional aspects of the p53... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Mutations; Neoplasia; Gene therapy; P53. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782012000500014 |
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| Faleiro,Mariana Batista Rodrigues; Croce,Giuliana Brasil; Toledo,Denise Caroline; Rodrigues,Marcela Marcondes Pinto; Batista,Aline Carvalho; Damasceno,Adilson Donizeti; Brito,Luiz Augusto Batista; Amorim,Renée Laufer; Moura,Veridiana Maria Brianezi Dignani de. |
| In this study the expression of metalloproteinases 2 (MMP-2) and 9 (MMP-9) in canine normal prostates and with proliferative disorders was evaluated to verify the role of these enzymes in extracellular matrix remodeling (ECM) and in the tissue invasion process. A total of 355 prostatic samples were obtained, from which 36 (10.1%) were normal prostates, 46 (13.0%) with benign prostatic hyperplasia (BPH), 128 (36.1%) with proliferative inflammatory atrophy (PIA), 74 (20.8%) with prostatic intraepithelial neoplasia (PIN), and 71 (20.0%) with prostatic carcinoma (PC). Difference in cytoplasmic immunohistochemical staining of MMP-2 and MMP-9 between acinar epithelium and periacinar stroma was found regarding the different diagnosis. The correlation between... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Dog; Gelatinases; Benign prostatic hyperplasia; Proliferative inflammatory atrophy; Prostatic intraepithelial neoplasia; Prostatic carcinoma. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782013000600015 |
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| Toledo,Denise Caroline; Faleiro,Mariana Batista Rodrigues; Rodrigues,Marcela Marcondes Pinto; Di Santis,Giovana Wingeter; Amorim,Renée Laufer; Moura,Veridiana Maria Brianezi Dignani de. |
| A atrofia inflamatória proliferativa (PIA) é uma lesão prostática pré-maligna de grande ocorrência na próstata humana e, mais recentemente, também observada em cães. Esta pesquisa teve por objetivo verificar os aspectos histomorfológicos da PIA na próstata canina. Foram utilizadas 43 próstatas de cães adultos, de várias raças e portes, e com histórico ou não de doença prostática. Os focos de PIA apresentaram epitélio displásico, formado por ácinos atróficos e com mais de uma camada de células de morfologia atípica, especialmente anisocitose, anisocariose, citoplasma reduzido, núcleo volumoso e com nucléolo evidente. As alterações epiteliais eram sempre acompanhadas de infiltrado inflamatório intersticial periacinar predominantemente linfocitário. Foi... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cão; PIA; Displasia prostática. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782010000600021 |
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| Faleiro,Mariana Batista Rodrigues; Cintra,Lorena Cardoso; Jesuino,Rosália Santos Amorim; Araújo,Eugênio Gonçalves de; Rocha,Rafael Malagoli; Moura,Veridiana Maria Brianezi Dignani de. |
| ABSTRACT: Gene expression of ErbB1 and ErbB2, and immunostaining of EGFR (Her1) and Her2 (c-erbB-2) were evaluated in this study to ascertain whether these receptors are involved in the evolution of canine premalignant and malignant prostatic lesions, as proliferative inflammatory atrophy (PIA) and prostatic carcinoma (PC). With regards to the intensity of EGFR immunostaining, there was no difference between normal prostatic tissue and tissues with PIA or PC. In relation to Her2 immunostaining, there were differences between normal prostatic tissue and those with PIA and PC, as also differences between prostates with PIA and PC. There was no correlation between EGFR and Her2 immunostaining. ErbB1 gene product was detected in two normal tissue samples, in... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Growth factor receptor; Her1; C-erbB-2; PIA; RT-PCR. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782017001200553 |
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