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| Oliveira Neto,M.G.; Santos,H.A.; Fraga,R.E.; Pacheco,A.S.; Sampaio,G.P.; Moura-Costa,L.F.; Meyer,R.; Silva,M. Costa; Trindade,S.C.; Vale,V.L.C.. |
| ABSTRACT This study aimed to evaluate aspects of host immune response using an experimental infection model of Corynebacterium pseudotuberculosis (CP) in C57/Black6 wild-type and knockout for nitric oxide (KO-NO) mice. 28 mice were evaluated: 4 wild-type controls; 10 wild-type infected with CP; 4 KO-NO controls; 10 KO-NO infected with CP. Infection procedures were carried out by intraperitoneal inoculation using 107. Infected C57/Black6 KO-NO mice began to die after the 5° day post-inoculation, up until the 14º day. Neutrophils were found in increased numbers in the infiltrate of KO-NO murine peritoneal cavities. Examination of splenic tissue revealed an accumulation of lymphocytes, predominantly CD8 T-cells, in experimental animal groups. KO-NO animals... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Nitric oxid; Knockout mice; Corynebacterium pseudotuberculosis; Caseous limphadenitis. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352017000601565 |
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