|
|
| Rivarola,E.W.R.; Moyses-Neto,M.; Dantas,M.; da-Silva,C.G.; Volpini,R.; Coimbra,T.M.. |
| Diabetic nephropathy (DN) is characterized structurally by progressive mesangial deposition of extracellular matrix (ECM). Transforming growth factor-ß (TGF-ß) is considered to be one of the major cytokines involved in the regulation of ECM synthesis and degradation. Several studies suggest that an increase in urinary TGF-ß levels may reflect an enhanced production of this polypeptide by the kidney cells. We evaluated TGF-ß in occasional urine samples from 14 normal individuals and 23 patients with type 2 diabetes (13 with persistent proteinuria >500 mg/24 h, DN, 6 with microalbuminuria, DMMA, and 4 with normal urinary albumin excretion, DMN) by enzyme immunoassay. An increase in the rate of urinary TGF-ß excretion (pg/mg UCreat.) was observed in... |
| Tipo: Info:eu-repo/semantics/other |
Palavras-chave: TGF-ß urinary excretion; Type 2 diabetes; Proteinuria; Diabetic nephropathy; Extracellular matrix. |
| Ano: 1999 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999001200011 |
| |
