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	Provedor de dados BABT (1) Autor Acar,Cigdem (1) Demir,Ilknur (1) Muftuler,Fazilet Zumrut Biber (1) Unak,Perihan (1) Palavra-chave 99mTc (1) Angiogenesis (1) Bevacizumab (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2011 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última In Vivo investigation of radiolabeled Bevacizumab in healthy rat tissues BABT Demir,Ilknur; Muftuler,Fazilet Zumrut Biber; Unak,Perihan; Acar,Cigdem. In this study, BevMab was conjugated with the bifunctional chelating agent [diethylenetriamine pentaacetic acid (DTPA)] and the product (BevMab-DTPA) was labeled with 99mTc using stannous chloride reducing method. The quality control studies of radiolabeled compound (99mTc-BevMab-DTPA) were done with Thin Layer Radio Chromatography (TLRC) and High Performance Liquid Radio Chromatography (HPLRC) methods (% 95 <) to confirm the labeling efficiency. High radiochemical yield [98.07 % ± 2.17 (n = 13)] was obtained by TLRC method. Biodistribution studies of 99mTc labeled BevMab-DTPA was run on healthy female and male Albino Wistar rats. The distribution figures demonstrated that the radiolabeled compound was eliminated through the kidneys and accumulated in... Tipo: Info:eu-repo/semantics/article Palavras-chave: Angiogenesis; Bevacizumab; 99mTc. Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000100010 Registros recuperados: 1 Primeira ... 1 ... Última

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