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Sociobiological Control of Plasmid copy number Nature Precedings
Mukta Watve; Milind Watve.
Background:
All known mechanisms and genes responsible for the regulation of plasmid replication lie with the plasmid rather than the chromosome. It is possible therefore that there can be copy-up mutants. Copy-up mutants will have within host selective advantage. This would eventually result into instability of bacteria-plasmid association. In spite of this possibility low copy number plasmids appear to exist stably in host populations. We examined this paradox using a computer simulation model.

Model:
Our multilevel selection model assumes a wild type with tightly regulated replication to ensure low copy number. A mutant with slightly relaxed replication regulation can act as a...
Tipo: Poster Palavras-chave: Ecology; Microbiology.
Ano: 2008 URL: http://precedings.nature.com/documents/2016/version/1
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