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	Provedor de dados BABT (1) Autor Mutlu,Ozal (1) Palavra-chave Docking (1) Homology modeling (1) Hydroperoxide metabolism (1) Leishmania donovani (1) Tryparedoxin peroxidase (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2014 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última In silico molecular modeling and docking studies on the leishmanial tryparedoxin peroxidase BABT Mutlu,Ozal. Leishmaniasis is one of the most common form of neglected parasitic disease that affects about 350 million people worldwide. Leishmanias have a trypanothione mediated hydroperoxide metabolism to eliminate endogenous or exogenous oxidative agents. Both of 2-Cys peroxiredoxin (Prx) and glutathione peroxidase type tryparedoxin peroxidase (Px) are the terminal enzymes in the trypanothione dependent detoxification system. Therefore absence of trypanothione redox system in mammals and the sensitivity of trypanosomatids against oxidative stress, enzymes of this pathway are drug targets candidates. In this study, 3D structure of tryparedoxin peroxidase (2-Cys peroxiredoxin type) from Leishmania donovani (LdTXNPx) was described by homology modeling method based on... Tipo: Info:eu-repo/semantics/article Palavras-chave: Homology modeling; Docking; Leishmania donovani; Tryparedoxin peroxidase; Hydroperoxide metabolism. Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132014000200013 Registros recuperados: 1 Primeira ... 1 ... Última

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