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Aspartate aminotransferase-to-platelet ratio index for fibrosis and cirrhosis prediction in chronic hepatitis C patients BJID
Silva Junior,Roberto Gomes da; Fakhouri,Ricardo; Nascimento,Tereza Virgínia Bezerra do; Santos,Igor Martins; Barbosa,Luciana Mendonça Morais.
In chronic hepatitis C (CHC), liver biopsy is the gold standard method for assessing liver histology, however it is invasive and can have complications. Non-invasive markers have been proposed and aspartate aminotransferase (AST)-to-platelet ratio index (APRI) has been shown as an easy and inexpensive marker of liver fibrosis. This study evaluated the diagnostic performance of APRI for significant fibrosis and cirrhosis prediction in CHC patients. This study included treatment-naive CHC patients who had undergone liver biopsy from January 2000 to August 2006. All histological slides were reviewed according to the METAVIR system. APRI was calculated based on laboratory results performed within four months from the biopsy. Twenty-eight (56%) patients had...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Chronic hepatitis C; Fibrosis; Cirrhosis; Liver biopsy; AP.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000100005
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