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| Menotti,Vinicius Stela; Scanferla,Deborah Thais Palma; Oliveira,Kleber Ota de; Fratucci,Gabriela Felber; Alves,Gessé de Souza; Bando,Erika; Nerilo,Samuel Botião; Oliveira,Magda Lúcia Félix de; Machinski Junior,Miguel; Mossini,Simone Aparecida Galerani. |
| Abstract The present study describes a method for simultaneous analysis of cocaine, benzoylecgonine and cocaethylene in urine samples. After solid phase extraction, Gas Chromatography-Mass Spectrometry was used for identification and quantification. The calibration curves were linear at 20 - 3000 ng/mL, r2 0.9997 for benzoylecgonine, 15 - 2000 ng/mL, r2 0.9985 and r2 0.9993 for cocaine and cocaethylene, respectively. Accuracy values: cocaine: 93,5 - 102,1%; benzoylecgonine: 97,5 - 104,8%; cocaethylene: 90,6 - 101,5%. Precision values: cocaine: C.V 5,4 - 14,6%; benzoylecgonine: C.V 7,8 - 12,3%; cocaethylene: C.V 5,9 - 12,3%. Detection and quantification limit values: cocaine and cocaethylene:10 ng/mL and 15 ng/mL, respectivalty; benzoylecgonine:15 ng/mL and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Analytical validation; GC-MS; Cocaine; Human urine. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100627 |
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| Nerilo,Samuel Botião; Martins,Fernanda Andrade; Nerilo,Luciana Botião; Salvadego,Valter Eduardo Cocco; Endo,Renan Yoshio; Rocha,Gustavo Henrique Oliveira; Mossini,Simone Aparecida Galerani; Janeiro,Vanderly; Nishiyama,Paula; Machinski Junior,Miguel. |
| A controlled cross-sectional study of family growers of fruit and vegetables was conducted between October 2009 and October 2010 to characterize the use of pesticides, establish the socio-demographic profile, and analyze cholinesterase activity in small-scale agricultural workers in Southern Brazil. Data was collected for 173 workers and 179 controls. A structured questionnaire was applied collecting socio-demographic information and determining knowledge and work practices in relation to pesticide use. The benchmarks for total cholinesterase (ChEs) and butyrylcholinesterase (BuChE) were obtained from the average enzymatic activity of the occupationally unexposed group (control). The mean age of the exposed population was 40.0 ± 11.2 years. The symptoms... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Pesticides/use; Pesticides/occupational exposure; Cholinesterase/evaluation/exposure to pesticides; Agricultural workers/exposure to pesticides; Environmental health; Brazil/southern/environmental health. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000400783 |
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| Santos,Alini Cristini dos; Souza,Aline Amenencia de; Silva,Milena Veronezi; Nerilo,Samuel Botião; Souza,Alexandra Perdigão Maia de; Bando,Érika; Machinski Junior,Miguel. |
| ABSTRACT: Peanuts are a nutritious food consumed worldwide. Some species of the genus Aspergillus, producers of aflatoxins, colonize peanuts. Human exposure to aflatoxins occurs by ingesting contaminated foods. The objective of this paper was to assess the occurrence and dietary exposure of the population to aflatoxins in peanuts commercially available in Maringa, Brazil, from May 2013 to April 2017. A total of 104 peanut samples were evaluated by thin-layer chromatography and confirmed by derivatization with trifluoroacetic acid. The contamination rate detected was 24.0% in average concentration of 13.4µg/kg. Twenty positive samples (19.2%) exceeded the maximum level permitted in Brazil for the sum of four aflatoxins. Estimated probable daily intake was... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Aflatoxins; Aspergillus flavus; Peanuts; Risk assessment; Public health. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782018000600750 |
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