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	Provedor de dados BJMBR (2) Autor Nery,J.A.C. (2) Azeredo-Coutinho,R.B.G. (1) Duppre,N.C. (1) Matos,D.C.S. (1) Matos,H.J.de (1) Mendonça,S.C.F. (1) Sales,A.M. (1) Sampaio,E.P. (1) Sarno,E.N. (1) Valete-Rosalino,C.M. (1) Mais... Palavra-chave Interferon-gamma (1) Interleukin-10 (1) Leishmania braziliensis (1) Lepromatous leprosy (1) Leprosy (1) Mucocutaneous leishmaniasis (1) Mycobacterium leprae (1) Pentoxifylline (1) Reactional episodes (1) Thalidomide (1) Therapy (1) Mais... Tipo do documento Info:eu-repo/semantics/other (2) Ano 2012 (1) 2007 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Interleukin-10-dependent down-regulation of interferon-gamma response to Leishmania by Mycobacterium leprae antigens during the clinical course of a coinfection BJMBR Azeredo-Coutinho,R.B.G.; Matos,D.C.S.; Nery,J.A.C.; Valete-Rosalino,C.M.; Mendonça,S.C.F.. We have described a case of a patient with an intriguing association of mucocutaneous leishmaniasis with lepromatous leprosy, two opposite polar forms of these spectral diseases. In the present follow-up study, we investigated the effect of the addition of Mycobacterium leprae antigens on interferon-gamma (IFN-γ) production in Leishmania antigen-stimulated cultures of peripheral blood mononuclear cells (PBMC) from this patient. For this purpose, PBMC cultures were stimulated with crude L. braziliensis and/or M. leprae whole-cell antigen extracts or with concanavalin A. In some experiments, neutralizing anti-human interleukin (IL)-10 antibodies were added to the cultures. IFN-γ and IL-10 levels in culture supernatants were measured by ELISA. During active... Tipo: Info:eu-repo/semantics/other Palavras-chave: Interferon-gamma; Interleukin-10; Mucocutaneous leishmaniasis; Lepromatous leprosy; Leishmania braziliensis; Mycobacterium leprae. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000700010 Double-blind trial of the efficacy of pentoxifylline vs thalidomide for the treatment of type II reaction in leprosy BJMBR Sales,A.M.; Matos,H.J.de; Nery,J.A.C.; Duppre,N.C.; Sampaio,E.P.; Sarno,E.N.. Type II reaction in leprosy, or erythema nodosum leprosum (ENL), is often characterized by severe clinical symptoms together with nerve function impairment leading to permanent disabilities. Thalidomide has been shown to be a highly effective drug for the treatment of ENL. It is, however, contraindicated for women of childbearing age due to its teratogenicity. On the other hand, pentoxifylline, used to treat hypercoagulable states, is not teratogenic and, like thalidomide, can inhibit the synthesis of tumor necrosis factor-a and other cytokines. In the present randomized double-blind clinical study we compared the effectiveness of orally administered pentoxifylline vs thalidomide in treating type II reaction in 44 patients. Daily doses of 300 mg... Tipo: Info:eu-repo/semantics/other Palavras-chave: Leprosy; Reactional episodes; Therapy; Pentoxifylline; Thalidomide. Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000200011 Registros recuperados: 2 Primeira ... 1 ... Última

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