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	Provedor de dados BJMBR (2) Autor Hirata,M.H. (2) Hirata,R.D.C. (2) Nguyen,N.Y. (2) Curi,R. (1) Ferraz,M.L.G. (1) Massirer,K.B. (1) Russo,M. (1) Silva,A.E.B. (1) Yoon,S. (1) Mais... Palavra-chave Autoimmune diseases (1) Chronic hepatitis C (1) Graft-versus-host disease (1) IFNAR1-mRNA expression (1) Inhibitor of interferon-a (1) Interferon alpha (1) Interferon-a receptor (1) Interferon-alpha receptor (1) Interferon-alpha therapy (1) Peripheral blood mononuclear cells (1) Recombinant protein (1) Reverse transcription- polymerase chain reaction (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Info:eu-repo/semantics/other (1) Ano 2004 (1) 2000 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Interferon-alpha receptor 1 mRNA expression in peripheral blood mononuclear cells is associated with response to interferon-alpha therapy of patients with chronic hepatitis C BJMBR Massirer,K.B.; Hirata,M.H.; Silva,A.E.B.; Ferraz,M.L.G.; Nguyen,N.Y.; Hirata,R.D.C.. Interferon (IFN)-alpha receptor mRNA expression in liver of patients with chronic hepatitis C has been shown to be a response to IFN-alpha therapy. The objective of the present study was to determine whether the expression of mRNA for subunit 1 of the IFN-alpha receptor (IFNAR1) in peripheral blood mononuclear cells (PBMC) is associated with the response to IFN-alpha in patients with chronic hepatitis C. Thirty patients with positive anti-HCV and HCV-RNA, and abnormal levels of alanine aminotransferase in serum were selected and treated with IFN-alpha2b for one year. Those with HBV or HIV infection, or using alcohol were not included. Thirteen discontinued the treatment and were not evaluated. The IFN-alpha response was monitored on the basis of alanine... Tipo: Info:eu-repo/semantics/other Palavras-chave: IFNAR1-mRNA expression; Interferon-alpha therapy; Chronic hepatitis C; Interferon-alpha receptor; Peripheral blood mononuclear cells; Reverse transcription- polymerase chain reaction. Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000500003 Expression and biological activity of two recombinant polypeptides related to subunit 1 of the interferon-a receptor BJMBR Yoon,S.; Hirata,R.D.C.; Nguyen,N.Y.; Curi,R.; Russo,M.; Hirata,M.H.. Abnormal production of interferon alpha (IFN-a) has been found in certain autoimmune diseases and can be also observed after prolonged therapy with IFN-a. IFN-a can contribute to the pathogenesis of allograft rejection in bone marrow transplants. Therefore, the development of IFN-a inhibitors as a soluble receptor protein may be valuable for the therapeutic control of these diseases. We have expressed two polypeptides encoding amino acids 93-260 (P1) and 261-410 (P2) of the extracellular domain of subunit 1 of the interferon-a receptor (IFNAR 1-EC) in E. coli. The activities of the recombinant polypeptides and of their respective antibodies were evaluated using antiproliferative and antiviral assays. Expression of P1 and P2 polypeptides was achieved by... Tipo: Info:eu-repo/semantics/article Palavras-chave: Interferon alpha; Interferon-a receptor; Inhibitor of interferon-a; Autoimmune diseases; Graft-versus-host disease; Recombinant protein. Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000700007 Registros recuperados: 2 Primeira ... 1 ... Última

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