|
|
|
|
|
| Oliveira,Robson Vicente Machado de; Ohara,Mitsuko Taba; Vila,Marta Maria Duarte Carvalho; Gonçalves,Marcos Moisés. |
| The capacity of copaíba oil to act as a skin penetration enhancer for the depigmenting agent kojic acid was evaluated using an in vitro diffusion system with static flux and shed rattlesnake skin membrane, Crotalus durissus terrificus, in saline solution at 34±2 ºC as the fluid receptor. The quantities of kojic acid liberated into the fluid receptor were determined by spectrophotometry at 268 nm with intervals of one and a half hours. The membranes, pretreated with copaíba oil at 25% and 50% v/v, gave flux values of 8.0 and 12.7 µg/cm²/h, permeability values of 2.0 and 3.3 cm×10-4/h, and promotion factors of 4.1 and 3.7, respectively. These results indicate that copaíba oil, at the two concentrations studied, has the capacity to promote penetration of... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Copaíba oil; Kojic acid. Skin penetration/in vitro studies; UV Spectrophotometry. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000200024 |
| |
|
|
| Macrini,Daclé Juliani; Suffredini,Ivana Barbosa; Varella,Antonio Drauzio; Younes,Riad Naim; Ohara,Mitsuko Taba. |
| Dermatological disorders related to pigmentation result in tenuous hyper or hypopigmentation Cosmetic and pharmaceutical products containing depigmenting substances are used in the treatment of patients who have high pigmentation disorders, such as melasma or chloasma, post-inflammatory hyperpigmentation, senile lentigo and ephelides. Skin lightening agents are not yet totally effective or safe and therefore intensive research for the discovery of new agents is continuous. Enzyme inhibitors involved in melanogenesis, such as tyrosinase, have been discovered in Asian countries, including those isolated from plant extracts. The Brazilian flora has the highest species diversity in the world, and the chemical, pharmacological and cosmetic potential for the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Tyrosinase; Melanin; Plant extract/in vitro evaluation; Skin lightening agents; Amazonian plants/evaluation/dermatological use. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000400015 |
| |
|
|
|
