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	Provedor de dados BJMBR (4) Autor Oliveira,A.L.R. (4) Damasceno,B.P. (1) Freria,C.M. (1) Langone,F. (1) Marques,K.B. (1) Maturana,L.G. (1) Pierucci,A. (1) Santos,L.M.B. (1) Scorisa,J.M. (1) Vidal,B.C. (1) Zanon,R. (1) Zanon,R.G. (1) Mais... Palavra-chave Isogenic mice (2) Apoptosis (1) Axotomy (1) Cell culture (1) Collagen (1) Experimental autoimmune encephalomyelitis (1) Glatiramer acetate (1) Immunomodulator (1) Motoneuron (1) Nerve regeneration (1) Nerve transplantation (1) Neuronal death (1) P75NTR (1) S-100 (1) Satellite cells (1) Schwann cells (1) Spinal cord (1) Supraorganized collagen (1) Synapse elimination (1) TUNEL (1) Mais... Tipo do documento Info:eu-repo/semantics/article (3) Info:eu-repo/semantics/other (1) Ano 2011 (1) 2009 (1) 2001 (1) 2000 (1) País Brazil (4) Idioma Inglês (4)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 4 Primeira ... 1 ... Última The immunomodulator glatiramer acetate influences spinal motoneuron plasticity during the course of multiple sclerosis in an animal model BJMBR Marques,K.B.; Scorisa,J.M.; Zanon,R.; Freria,C.M.; Santos,L.M.B.; Damasceno,B.P.; Oliveira,A.L.R.. The immunomodulador glatiramer acetate (GA) has been shown to significantly reduce the severity of symptoms during the course of multiple sclerosis and in its animal model - experimental autoimmune encephalomyelitis (EAE). Since GA may influence the response of non-neuronal cells in the spinal cord, it is possible that, to some extent, this drug affects the synaptic changes induced during the exacerbation of EAE. In the present study, we investigated whether GA has a positive influence on the loss of inputs to the motoneurons during the course of EAE in rats. Lewis rats were subjected to EAE associated with GA or placebo treatment. The animals were sacrificed after 15 days of treatment and the spinal cords processed for immunohistochemical analysis and... Tipo: Info:eu-repo/semantics/article Palavras-chave: Experimental autoimmune encephalomyelitis; Spinal cord; Synapse elimination; Motoneuron; Immunomodulator; Glatiramer acetate. Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000200006 Apoptosis of sensory neurons and satellite cells after sciatic nerve transection in C57BL/6J mice BJMBR Oliveira,A.L.R.. The rate of axonal regeneration, after sciatic nerve lesion in adult C57BL/6J mice, is reduced when compared to other isogenic strains. It was observed that such low regeneration was not due just to a delay, since neuronal death was observed. Two general mechanisms of cell death, apoptosis and necrosis, may be involved. By using the terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) technique, we demonstrated that a large number of sensory neurons, as well as satellite cells found in the dorsal root ganglia, were intensely labeled, thus indicating that apoptotic mechanisms were involved in the death process. Although almost no labeled neurons or satellite cells were observed one week after transection, a more than ten-fold increase in... Tipo: Info:eu-repo/semantics/other Palavras-chave: TUNEL; Apoptosis; Axotomy; Neuronal death; Satellite cells; Isogenic mice. Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000300012 Supraorganized collagen enhances Schwann cell reactivity and organization in vitro BJMBR Maturana,L.G.; Zanon,R.G.; Pierucci,A.; Vidal,B.C.; Oliveira,A.L.R.. We investigated the reactivity and expression of basal lamina collagen by Schwann cells (SCs) cultivated on a supraorganized bovine-derived collagen substrate. SC cultures were obtained from sciatic nerves of neonatal Sprague-Dawley rats and seeded on 24-well culture plates containing collagen substrate. The homogeneity of the cultures was evaluated with an SC marker antibody (anti-S-100). After 1 week, the cultures were fixed and processed for immunocytochemistry by using antibodies against type IV collagen, S-100 and p75NTR (pan neurotrophin receptor) and for scanning electron microscopy (SEM). Positive labeling with antibodies to the cited molecules was observed, indicating that the collagen substrate stimulates SC alignment and adhesion (collagen IV... Tipo: Info:eu-repo/semantics/article Palavras-chave: S-100; P75NTR; Type IV collagen; Collagen; Cell culture; Supraorganized collagen. Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000700011 Non-neuronal cells are not the limiting factor for the low axonal regeneration in C57BL/6J mice BJMBR Oliveira,A.L.R.; Langone,F.. Peripheral axonal regeneration was investigated in adult male mice of the C57BL/6J (C), BALB/cJ (B) and A/J (A) strains and in their F1 descendants using a predegenerated nerve transplantation model. Four types of transplants were performed: 1) isotransplants between animals of the C, B and A strains; 2) donors of the C strain and recipients of the C x B and C x A breeding; 3) donors of the B strain and recipients of the C x B breeding, and 4) donors of the A strain and recipients of the C x A breeding. Donors had the left sciatic nerve transected and two weeks later a segment of the distal stump was transplanted into the recipient. Four weeks after transplantation the regenerated nerves were used to determine the total number of regenerated myelinated... Tipo: Info:eu-repo/semantics/article Palavras-chave: Nerve regeneration; Schwann cells; Isogenic mice; Nerve transplantation; Tubulization. Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000001200011 Registros recuperados: 4 Primeira ... 1 ... Última

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