Home Itens selecionados Provedores de dados OAI Créditos Sobre Ajuda

			Busca avançada
	Provedor de dados BJMBR (2) Autor Oliveira,M.L.S. (2) Brochado,S.M. (1) Carvalho,E. (1) Ho,P.L. (1) Miyaji,E.N. (1) Raw,I. (1) Sogayar,M.C. (1) Mais... Palavra-chave Adjuvant (1) DAMP (1) Innate immunity (1) Malignant transformation (1) PAMP (1) Polyomavirus T antigens (1) Polyomavirus-induced transcriptional control (1) Signal transduction (1) Vaccine (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2011 (1) 1999 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Mechanisms of cell transformation induced by polyomavirus BJMBR Oliveira,M.L.S.; Brochado,S.M.; Sogayar,M.C.. Polyomavirus is a DNA tumor virus that induces a variety of tumors in mice. Its genome encodes three proteins, namely large T (LT), middle T (MT), and small T (ST) antigens, that have been implicated in cell transformation and tumorigenesis. LT is associated with cell immortalization, whereas MT plays an essential role in cell transformation by binding to and activating several cytoplasmic proteins that participate in growth factor-induced mitogenic signal transduction to the nucleus. The use of different MT mutants has led to the identification of MT-binding proteins as well as analysis of their importance during cell transformation. Studying the molecular mechanisms of cell transformation by MT has contributed to a better understanding of cell cycle... Tipo: Info:eu-repo/semantics/article Palavras-chave: Signal transduction; Malignant transformation; Polyomavirus T antigens; Polyomavirus-induced transcriptional control. Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000700010 Trends in adjuvant development for vaccines: DAMPs and PAMPs as potential new adjuvants BJMBR Miyaji,E.N.; Carvalho,E.; Oliveira,M.L.S.; Raw,I.; Ho,P.L.. Aluminum salts have been widely used in vaccine formulations and, after their introduction more than 80 years ago, only few vaccine formulations using new adjuvants were developed in the last two decades. Recent advances in the understanding of how innate mechanisms influence the adaptive immunity opened up the possibility for the development of new adjuvants in a more rational design. The purpose of this review is to discuss the recent advances in this field regarding the attempts to determine the molecular basis and the general mechanisms underlying the development of new adjuvants, with particular emphasis on the activation of receptors of innate immune recognition. One can anticipate that the use of these novel adjuvants will also provide a window of... Tipo: Info:eu-repo/semantics/article Palavras-chave: Adjuvant; Vaccine; Innate immunity; DAMP; PAMP. Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000600003 Registros recuperados: 2 Primeira ... 1 ... Última

Empresa Brasileira de Pesquisa Agropecuária - Embrapa Todos os direitos reservados, conforme Lei n° 9.610 Política de Privacidade Área restrita		Embrapa Parque Estação Biológica - PqEB s/n° Brasília, DF - Brasil - CEP 70770-901 Fone: (61) 3448-4433 - Fax: (61) 3448-4890 / 3448-4891 SAC: https://www.embrapa.br/fale-conosco