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| Oliveira,Marcelo Antonio de; Lacerda,Caroline Dutra; Bonella,André Fazôlo. |
| Atorvastatin (ATV) is an antilipemic drug of great interest to the pharmaceutical industry. ATV does not appear in the monographs of Brazilian pharmacopoeia, and analytical methodologies for its determination have been validated. The chromatographic conditions used included: RP-18 column-octadecylsilane (250 x 4.6 mm, 5 mm), detection at 238 nm, mobile phase containing 0.1% phosphoric acid and acetonitrile (35:65% v/v), flow at 1.5 mL min-1, oven temperature at 30ºC, and injection volume of 10 mL. ATV is classified as a class II product, according to the biopharmaceutical classification system. As such, a dissolution test was proposed to evaluate pharmaceutical formulations on the market today, under the following conditions: water as a dissolution medium,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Pharmaceutical formulations/evaluation; Atorvastatin; Drugs/dissolution test; Drugs/qualitative analysis. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000400024 |
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| Oliveira,Marcelo Antonio de; Silva,Gerliane Damázio da; Campos,Michele Soares Tacchi. |
| ABSTRACT Fibrates are drugs used for the treatment of hypertriglyceridemia and for the prevention of atherosclerosis. Three drugs in the fibrate class, ciprofibrate, fenofibrate and bezafibrate, were chosen for this study because their raw materials are readily available and because scientific publications on these compounds is limited. To evaluate their intrinsic stability, the drugs were exposed to a test condition (temperature, oxidation, UV light exposure, hydrolysis at different pH values and metal ions in solution) and then were subjected to analysis by HPLC. The samples were run on a C18 column, with a flow rate of 1.0 mL min-1 in a mobile phase consisting of methanol: 0.01 % phosphoric acid v/v (80:20), with variable detection wavelengths in the UV... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Hypertriglyceridemia/fibrates; Fibrates stability/study; Fibrates degradation products/High Perfomance Liquid Chromatography (HPLC); Fibrates/Degradation kinetics.. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000300545 |
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