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Oxidative stress action in cellular aging BABT
Oliveira,Monique Cristine de; Schoffen,João Paulo Ferreira.
Various theories try to explain the biological aging by changing the functions and structure of organic systems and cells. During lifetime, free radicals in the oxidative stress lead to lipid peroxidation of cellular membranes, homeostasis imbalance, chemical residues formation, gene mutations in DNA, dysfunction of certain organelles, and the arise of diseases due to cell death and/or injury. This review describes the action of oxidative stress in the cells aging process, emphasizing the factors such as cellular oxidative damage, its consequences and the main protective measures taken to prevent or delay this process. Tests with antioxidants: vitamins A, E and C, flavonoids, carotenoids and minerals, the practice of caloric restriction and physical...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Antioxidants; Cellular aging; Cell death; Oxidative stress.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132010000600009
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Use of Ursodeoxycholic Acid on Post-menopausal Obesity, Hepatic steatosis and Plasma Profile as an Alternative Treatment for Hormone Replacement Therapy BABT
Franzoni,Angelo Christiano; Amorim,Aryane Martins; Silva,João Victor Mariano da; Storti,João Augusto Pires; Oliveira,Monique Cristine de.
ABSTRACT The aim of this study was to evaluate the efficacy of the ursodeoxycholic acid (UDCA) as an alternative treatment for menopause pathologies. For this, female Swiss-CD-1 mice were ovariectomized (OVX); SHAM operated mice served as controls. Ten weeks after operation, each group of mice was treated during four weeks with either UDCA, or 17(-estradiol+progesterone. The blood and tissues (liver and periuterine adipose tissue - PUAT) were harvested. The OVX mice had increase body weight, accompanied by liver lipid accumulation. UDCA and HRT treatments reduced these parameters. PUAT was also increased in OVX group and UDCA and HRT treatments reduced this. Histology confirmed the results in the liver and PUAT. The plasma glucose levels were elevated in...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Liver disease; Menopause; Obesity; Ursodeoxycholic acid.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132015000600898
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