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	Provedor de dados BJM (2) BJPS (1) Autor Oliveira,Valéria de (3) Pimenta,Fabiana Cristina (2) Andrade,Carolina Horta (1) Bueno,Elda (1) Costa,Eula Maria de M. B (1) Costa,Eula Maria de M. B. (1) Freitas,Lenis Medeiros de (1) Luz,Christian (1) Luz,Wolf Christian (1) Oliveira,Marília (1) Petrofeza,Silvana (1) Mais... Palavra-chave Biotransformation (2) 3-dioxygenase genetic diversity (1) AIDS/treatment (1) Antiretroviral drugs (1) Beauveria bassiana (1) Beauveria bassiana quercetinase quercetin-2 (1) Drugs/anti-HIV (1) Drugs/metabolism (1) Quercetin (1) Mais... Tipo do documento Info:eu-repo/semantics/article (3) Ano 2011 (2) 2008 (1) País Brazil (3) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Beauveria bassiana: quercetinase production and genetic diversity BJM Costa,Eula Maria de M. B; Pimenta,Fabiana Cristina; Luz,Christian; Oliveira,Valéria de; Oliveira,Marília; Bueno,Elda; Petrofeza,Silvana. Beauveria bassiana genetic diversity and ability to synthesize quercetin 2,3-dioxygenase (quercetinase) were analyzed. B. bassiana isolates, obtained from Brazilian soil samples, produced quercetinase after induction using 0.5 g/L quercetin. B. bassiana ATCC 7159 (29.6 nmol/mL/min) and isolate IP 11 (27.5 nmol/ml/min) showed the best performances and IP 3a (9.5 nmol/mL/min) presented the lowest level of quercetinase activity in the culture supernatant. A high level of polymorphism was detected by random amplified polymorphic DNA (RAPD) analysis. The use of internal-transcribed-spacer ribosomal region restriction fragment length polymorphism (ITS-RFLP) did not reveal characteristic markers to differentiate isolates. However, the ITS1-5.8S-ITS2 region... Tipo: Info:eu-repo/semantics/article Palavras-chave: Beauveria bassiana quercetinase quercetin-2; 3-dioxygenase genetic diversity. Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822011000100002 Selection of filamentous fungi of the Beauveria genus able to metabolize quercetin like mammalian cells BJM Costa,Eula Maria de M. B.; Pimenta,Fabiana Cristina; Luz,Wolf Christian; Oliveira,Valéria de. Microbial biotransformations constitute an important alternative as models for drug metabolism study in mammalians and have been used for the industrial synthesis of chemicals with pharmaceutical purposes. Several microorganisms with unique biotransformation ability have been found by intensive screening and put in commercial applications. Ten isolates of Beauveria sp genus filamentous fungi, isolated from soil in the central Brazil, and Beauveria bassiana ATCC 7159 were evaluated for their capability of quercetin biotransformation. Biotransformation processes were carried out for 24 up to 96 hours and monitored by mass spectrometry analyses of the culture broth. All strains were able to metabolize quercetin, forming mammalian metabolites. The results were... Tipo: Info:eu-repo/semantics/article Palavras-chave: Beauveria bassiana; Biotransformation; Quercetin. Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822008000200036 Twenty-six years of HIV science: an overview of anti-HIV drugs metabolism BJPS Andrade,Carolina Horta; Freitas,Lenis Medeiros de; Oliveira,Valéria de. From the identification of HIV as the agent causing AIDS, to the development of effective antiretroviral drugs, the scientific achievements in HIV research over the past twenty-six years have been formidable. Currently, there are twenty-five anti-HIV compounds which have been formally approved for clinical use in the treatment of AIDS. These compounds fall into six categories: nucleoside reverse transcriptase inhibitors (NRTIs), nucleotide reverse transcriptase inhibitors (NtRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs), protease inhibitors (PIs), cell entry inhibitors or fusion inhibitors (FIs), co-receptor inhibitors (CRIs), and integrase inhibitors (INIs). Metabolism by the host organism is one of the most important determinants of the... Tipo: Info:eu-repo/semantics/article Palavras-chave: AIDS/treatment; Drugs/anti-HIV; Drugs/metabolism; Antiretroviral drugs; Biotransformation. Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000200003 Registros recuperados: 3 Primeira ... 1 ... Última

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