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| Loureiro,Melina Bezerra; Ururahy,Marcela Abbott Galvão; Souza,Karla Simone Costa de; Oliveira,Yonara Monique da Costa; Silva,Heglayne Pereira Vital da; Bortolin,Raul Hernandes; Bezerra,João Felipe; Hirata,Rosario Dominguez Crespo; Maciel-Neto,José Jorge; Arrais,Ricardo Fernando; Almeida,Maria das Graças; Hirata,Mario Hiroyuki; Rezende,Adriana Augusto de. |
| ABSTRACT The aim of the present study was to investigate the bone mineral density (BMD) of patients with type 1 Diabetes mellitus (T1DM). We also assessed the association between osteoprotegerin (OPG) genetic polymorphisms and BMD. Genotyping was performed for 1181G>C and 163A>G OPG polymorphisms by allelic discrimination in 119 patients with T1DM and 161 normoglycemic (NG) individuals, aged 6 to 20 years old. Glycemic control, serum parameters of bone metabolism and BMD were evaluated. T1DM patients showed low BMD, poor glycemic control and decreased total calcium values when compared to controls (p < 0.05). For all the polymorphisms studied, the genotype and allele frequencies in patients with T1DM were not significantly different from the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Type 1 Diabetes mellitus/bone biomarkers; Bone mineral density; OPG polymorphism/children and adolescents. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000400616 |
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