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| Kuzmina, N.; Ellison, J.; Orciari, L.; Marissen, W.; Kuzmin, I.; Rupprecht, C.. |
| The demand for rabies immune globulin (RIG) for post-exposure prophylaxis (PEP) is significant. Unfortunately, the cost of RIG is prohibitive for many patients in developing countries. Several monoclonal antibodies (MAbs) which neutralize rabies virus (RABV) have been proposed as a replacement for conventional RIG due to the ability of their large-scale production at a reduced cost. In the present study, we generated 487 RABV glycoprotein (G) sequences from a variety of viral lineages, and supplemented the dataset with 154 complete and 115 partial G sequences available in GenBank. The objective was to evaluate variability of known MAb-binding epitopes on the G, which may preclude virus neutralization. The analysis demonstrated that binding site of MAb CR57... |
| Tipo: Info:eu-repo/semantics/article |
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| Ano: 2013 |
URL: http://www.revistamvez-crmvsp.com.br/index.php/recmvz/article/view/247 |
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