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| Cárdenas,Paola Andrea; Kratz,Jadel Müller; Hernández,Aura; Costa,Geison Modesti; Ospina,Luis Fernando; Baena,Yolima; Simões,Cláudia Maria Oliveira; Jimenez-Kairuz,Álvaro; Aragon,Marcela. |
| ABSTRACT 6-Methylcoumarin (6MC) is a semisynthetic coumarin with important in vitro and in vivo anti-inflammatory activity. In order to continue the pre-clinical characterization of this molecule, in vitro intestinal permeability, plasma profile and tissue distribution after oral administration in rats were studied. The permeability of 6MC was evaluated by the Caco-2 cellular model in both the apical-basal (A-B) and basal-apical (B-A) directions. The pharmacokinetics and biodistribution were evaluated in rats after oral and intraperitoneal administration at doses of 200 mg/kg. Transport experiments with Caco-2 cells showed that 6MC presented high permeability at all concentrations evaluated. This finding suggested that 6MC could be transported across the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: 6-Methylcoumarin/Pharmacokinetics/rats; 6-Methylcoumarin/distribution; Intestinal permeability/study; Intestinal permeability/study/In vitro. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000100621 |
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