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Schwann cells for spinal cord repair BJMBR
Oudega,M.; Moon,L.D.F.; de Almeida Leme,R.J..
The complex nature of spinal cord injury appears to demand a multifactorial repair strategy. One of the components that will likely be included is an implant that will fill the area of lost nervous tissue and provide a growth substrate for injured axons. Here we will discuss the role of Schwann cells (SCs) in cell-based, surgical repair strategies of the injured adult spinal cord. We will review key studies that showed that intraspinal SC grafts limit injury-induced tissue loss and promote axonal regeneration and myelination, and that this response can be improved by adding neurotrophic factors or anti-inflammatory agents. These results will be compared with several other approaches to the repair of the spinal cord. A general concern with repair strategies...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Spinal cord injury; Implantation; Regeneration; Neurotrophic factors; Clinical trial; Rehabilitation; Gene profiling.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000600003
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