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	Provedor de dados BJMBR (1) Autor Del Bel,E.A. (1) Novaretti,N. (1) Padovan-Neto,F.E. (1) Tumas,V. (1) da-Silva,C.A. (1) Palavra-chave 7-Nitroindazole (1) DOPA priming (1) Dyskinesia (1) L-DOPA (1) Nitric oxide (1) Nitric oxide synthase (1) Parkinson’s disease (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Ano 2010 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Lack of tolerance for the anti-dyskinetic effects of 7-nitroindazole, a neuronal nitric oxide synthase inhibitor, in rats BJMBR Novaretti,N.; Padovan-Neto,F.E.; Tumas,V.; da-Silva,C.A.; Del Bel,E.A.. 7-Nitroindazole (7-NI) inhibits neuronal nitric oxide synthase in vivo and reduces l-DOPA-induced dyskinesias in a rat model of parkinsonism. The aim of the present study was to determine if the anti-dyskinetic effect of 7-NI was subject to tolerance after repeated treatment and if this drug could interfere with the priming effect of l-DOPA. Adult male Wistar rats (200-250 g) with unilateral depletion of dopamine in the substantia nigra compacta were treated with l-DOPA (30 mg/kg) for 34 days. On the 1st day, 6 rats received ip saline and 6 received ip 7-NI (30 mg/kg) before l-DOPA. From the 2nd to the 26th day, all rats received l-DOPA daily and, from the 27th to the 34th day, they also received 7-NI before l-DOPA. Animals were evaluated before the drug... Tipo: Info:eu-repo/semantics/article Palavras-chave: Nitric oxide; Nitric oxide synthase; Parkinson’s disease; L-DOPA; Dyskinesia; DOPA priming; 7-Nitroindazole. Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010001100006 Registros recuperados: 1 Primeira ... 1 ... Última

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