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	Provedor de dados BJMBR (2) Autor Paiva,A.C.M. (2) Felipe,S.A. (1) Han,S.W. (1) Kanashiro,C.A. (1) Krieger,J.E. (1) Martin,R.P. (1) Merjan,A.J. (1) Pesquero,J.B. (1) Rodrigues,E.S. (1) Shimuta,S.I. (1) Mais... Palavra-chave Agonist-induced receptor internalization (1) Angiotensin II (1) Bradykinin (1) DesArg9bradykinin (1) Endocytosis (1) Fluorescence-tagged receptor (1) Indomethacin (1) Kinin B1 and B2 receptors (1) L-NAME (1) Nuclear angiotensin receptors (1) Renin-angiotensin system (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2007 (1) 2001 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Ligand-induced endocytosis and nuclear localization of angiotensin II receptors expressed in CHO cells BJMBR Merjan,A.J.; Kanashiro,C.A.; Krieger,J.E.; Han,S.W.; Paiva,A.C.M.. A construct (AT1R-NF) containing a "Flag" sequence added to the N-terminus of the rat AT1 receptor was stably expressed in Chinese hamster ovary cells and quantified in the cell membrane by confocal microscopy after reaction with a fluorescein-labeled anti-Flag monoclonal antibody. Angiotensin II bound to AT1R-NF and induced endocytosis with a half-time of 2 min. After 60-90 min, fluorescence accumulated around the cell nucleus, suggesting migration of the ligand-receptor complex to the nuclear membrane. Angiotensin antagonists also induced endocytosis, suggesting that a common step in the transduction signal mechanism occurring after ligand binding may be responsible for the ligand-receptor complex internalization. Tipo: Info:eu-repo/semantics/article Palavras-chave: Angiotensin II; Agonist-induced receptor internalization; Endocytosis; Fluorescence-tagged receptor; Nuclear angiotensin receptors; Renin-angiotensin system. Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000900011 Functional expression of kinin B1 and B2 receptors in mouse abdominal aorta BJMBR Felipe,S.A.; Rodrigues,E.S.; Martin,R.P.; Paiva,A.C.M.; Pesquero,J.B.; Shimuta,S.I.. Previous studies have shown that the vascular reactivity of the mouse aorta differs substantially from that of the rat aorta in response to several agonists such as angiotensin II, endothelin-1 and isoproterenol. However, no information is available about the agonists bradykinin (BK) and DesArg9BK (DBK). Our aim was to determine the potential expression of kinin B1 and B2 receptors in the abdominal mouse aorta isolated from C57BL/6 mice. Contraction and relaxation responses to BK and DBK were investigated using isometric recordings. The kinins were unable to induce relaxation but concentration-contraction response curves were obtained by applying increasing concentrations of the agonists BK and DBK. These effects were blocked by the antagonists Icatibant... Tipo: Info:eu-repo/semantics/article Palavras-chave: Kinin B1 and B2 receptors; Bradykinin; DesArg9bradykinin; Indomethacin; L-NAME. Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000500007 Registros recuperados: 2 Primeira ... 1 ... Última

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