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Chondrogenic Differentiation of Bone Marrow Mesenchymal Stem Cells: First Successful Latin-American Report International Journal of Morphology
Mardones,Rodrigo; Martínez,Rafael; Paredes,María Jose; Zalaquett,Eugenio.
Osteoarthritis is the more frequent cause of disability in adult people and it is associated to cartilage degeneration of affected joints. This cartilage has a limited ability to repair. Several treatments have been tested including the use of Mesenchymal Stem Cells. These cells are an attractive source for cartilage repair because of their availability to chodrogenic differentiation by progressing sequentially through the expression of cartilage specific extracelullar matrix molecules, as in the embryologic human development. The aim is to obtain, culture and differentiate rabbit Bone Marrow derived Mesenchymal Stem Cells in vitro to chondral lineage. By differential centrifugation the mononuclear cell level was obtained from rabbit bone marrow samples....
Tipo: Journal article Palavras-chave: Chondrogenic differentiation; Mesenchymal Stem Cells; Osteoarthritis.
Ano: 2010 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000300014
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