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| Viecili,P.R.; Pamplona,D.; Park,M.; Silva,S.R.; Ramires,J.A.F.; Da Luz,P.L.. |
| The concomitant use of angiotensin-converting enzyme inhibitors and aspirin may cause pharmacological antagonism. Hence we examined the effect of aspirin on the neurohormonal function and hemodynamic response to captopril in heart failure patients. Between April 1999 and August 2000, 40 patients were randomized into four equal groups: 1) captopril, 2) aspirin, 3) captopril-aspirin: captopril was given alone on the first day, followed by aspirin on the remaining days, and 4) aspirin-captopril: aspirin was given alone on the first day, followed by captopril on the remaining days. Hemodynamic, norepinephrine and prostaglandin measurements were performed pre- and post-medication for 4 days. Captopril (50 mg) was given orally every 8 h and 300 mg aspirin was... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Pharmacological antagonism; Aspirin; Angiotensin-converting enzyme inhibitors; Decompensated heart failure; Hemodynamics and neurohormonal changes. |
| Ano: 2003 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000600013 |
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| Park,M.; A.T.,Maciel; Noritomi,D.T.; Brunialti,M.K.; Salomão,R.; Schettino,G.P.P.; Azevedo,L.C.P.. |
| We evaluated the recovery of cardiovascular function after transient cardiogenic shock. Cardiac tamponade was performed for 1 h and post-shock data were collected in 5 domestic large white female pigs (43 ± 5 kg) for 6 h. The control group (N = 5) was observed for 6 h after 1 h of resting. During 1 h of cardiac tamponade, experimental animals evolved a low perfusion status with a higher lactate level (8.0 ± 2.2 vs 1.9 ± 0.9 mEq/L), lower standard base excess (-7.3 ± 3.3 vs 2.0 ± 0.9 mEq/L), lower urinary output (0.9 ± 0.9 vs 3.0 ± 1.4 mL·kg-1·h-1), lower mixed venous saturation, higher ileum partial pressure of CO2-end tidal CO2 (EtCO2) gap and a lower cardiac index than the control group. Throughout the 6-h recovery phase after cardiac tamponade,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cardiogenic shock; Cardiac tamponade; Systemic inflammatory response syndrome; Swine; Myocardial dysfunction; Inflammation. |
| Ano: 2008 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000800002 |
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| Ranzani,O.T.; Battaini,L.C.; Moraes,C.E.; Prada,L.F.L.; Pinaffi,J.V.; Giannini,F.P.; Shinjo,S.K.; Azevedo,L.C.P.; Park,M.. |
| Our objective was to compare the pattern of organ dysfunctions and outcomes of critically ill patients with systemic lupus erythematosus (SLE) with patients with other systemic rheumatic diseases (SRD). We studied 116 critically ill SRD patients, 59 SLE and 57 other-SRD patients. The SLE group was younger and included more women. Respiratory failure (61%) and shock (39%) were the most common causes of ICU admission for other-SRD and SLE groups, respectively. ICU length-of-stay was similar for the two groups. The 60-day survival adjusted for the groups’ baseline imbalances was not different (P = 0.792). Total SOFA scores were equal for the two groups at admission and during ICU stay, although respiratory function was worse in the other-SRD group at... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Critical illness; Rheumatic diseases; Systemic lupus erythematosus; Intensive care units; Multiple organ failure; Patient outcome assessment. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011001100016 |
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