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Mechanisms underlying gas exchange alterations in an experimental model of pulmonary embolism BJMBR
Ferreira,J.H.T.; Terzi,R.G.G.; Paschoal,I.A.; Silva,W.A.; Moraes,A.C.; Moreira,M.M..
The aim of the present study was to determine the ventilation/perfusion ratio that contributes to hypoxemia in pulmonary embolism by analyzing blood gases and volumetric capnography in a model of experimental acute pulmonary embolism. Pulmonary embolization with autologous blood clots was induced in seven pigs weighing 24.00 ± 0.6 kg, anesthetized and mechanically ventilated. Significant changes occurred from baseline to 20 min after embolization, such as reduction in oxygen partial pressures in arterial blood (from 87.71 ± 8.64 to 39.14 ± 6.77 mmHg) and alveolar air (from 92.97 ± 2.14 to 63.91 ± 8.27 mmHg). The effective alveolar ventilation exhibited a significant reduction (from 199.62 ± 42.01 to 84.34 ± 44.13) consistent with the fall in alveolar gas...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Effective alveolar ventilation; Mismatching ventilation/ perfusion; Pulmonary gas exchange.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000900007
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