Home Itens selecionados Provedores de dados OAI Créditos Sobre Ajuda

			Busca avançada
	Provedor de dados BJMBR (2) Autor Paula,R.S. (2) Alves,E.S. (1) Avakian,S.D. (1) Donzella,H. (1) Gomes,L.O. (1) Henriques,A.D. (1) Mansur,A.P. (1) Moraes,C.F. (1) Nóbrega,O.T. (1) Ramires,J.A.F. (1) Santos,S.R.C.J. (1) Tonet-Furioso,A.C. (1) Mais... Palavra-chave Apolipoprotein B (1) Arterial hypertension (1) Diet (1) Elderly (1) Genetic polymorphism (1) Hyperlipidemia (1) Pharmacodynamics (1) Pharmacokinetics (1) Propranolol (1) Sublingual vs peroral administration (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2020 (1) 1998 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última The APOB rs693 polymorphism impacts the lipid profile of Brazilian older adults BJMBR Alves,E.S.; Henriques,A.D.; Tonet-Furioso,A.C.; Paula,R.S.; Gomes,L.O.; Moraes,C.F.; Nóbrega,O.T.. The apolipoprotein B (APOB) gene contains several polymorphic sites described as risk modifiers for cardiovascular events. The objective of this study was to verify the association of the classic APOB Xba I polymorphism (rs693) with atherosclerotic risk factors in a segment of the Brazilian elderly population considering their usual dietary intake. Clinical and biochemical characteristics as well as total caloric and fat intake data were determined from 644 elderly individuals. Polymorphism analysis was performed by conventional polymerase chain reaction followed by enzyme restriction. Statistical analyses compared measures and proportions according to different APOB genotypic combinations. Statistically significant association was found between Xba I... Tipo: Info:eu-repo/semantics/article Palavras-chave: Apolipoprotein B; Genetic polymorphism; Elderly; Hyperlipidemia; Diet. Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2020000300608 Pharmacokinetics and pharmacodynamics of propranolol in hypertensive patients after sublingual administration: systemic availability BJMBR Mansur,A.P.; Avakian,S.D.; Paula,R.S.; Donzella,H.; Santos,S.R.C.J.; Ramires,J.A.F.. The bioavailability of propranolol depends on the degree of liver metabolism. Orally but not intravenously administered propranolol is heavily metabolized. In the present study we assessed the pharmacokinetics and pharmacodynamics of sublingual propranolol. Fourteen severely hypertensive patients (diastolic blood pressure (DBP) <FONT FACE="Symbol">³</font>115 mmHg), aged 40 to 66 years, were randomly chosen to receive a single dose of 40 mg propranolol hydrochloride by sublingual or peroral administration. Systolic (SBP) and diastolic (DBP) blood pressures, heart rate (HR) for pharmacodynamics and blood samples for noncompartmental pharmacokinetics were obtained at baseline and at 10, 20, 30, 60 and 120 min after the single dose. Significant... Tipo: Info:eu-repo/semantics/article Palavras-chave: Propranolol; Pharmacokinetics; Pharmacodynamics; Arterial hypertension; Sublingual vs peroral administration. Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000500014 Registros recuperados: 2 Primeira ... 1 ... Última

Empresa Brasileira de Pesquisa Agropecuária - Embrapa Todos os direitos reservados, conforme Lei n° 9.610 Política de Privacidade Área restrita		Embrapa Parque Estação Biológica - PqEB s/n° Brasília, DF - Brasil - CEP 70770-901 Fone: (61) 3448-4433 - Fax: (61) 3448-4890 / 3448-4891 SAC: https://www.embrapa.br/fale-conosco