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	Provedor de dados BJMBR (1) Autor Kettelhut,I.C. (1) Manfredi,L.H. (1) Paula-Gomes,S. (1) Zanon,N.M. (1) Palavra-chave Cardiomyocytes (1) Myostatin (1) Protein degradation (1) Protein synthesis (1) Skeletal muscle (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2017 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Myostatin promotes distinct responses on protein metabolism of skeletal and cardiac muscle fibers of rodents BJMBR Manfredi,L.H.; Paula-Gomes,S.; Zanon,N.M.; Kettelhut,I.C.. Myostatin is a novel negative regulator of skeletal muscle mass. Myostatin expression is also found in heart in a much less extent, but it can be upregulated in pathological conditions, such as heart failure. Myostatin may be involved in inhibiting protein synthesis and/or increasing protein degradation in skeletal and cardiac muscles. Herein, we used cell cultures and isolated muscles from rats to determine protein degradation and synthesis. Muscles incubated with myostatin exhibited an increase in proteolysis with an increase of Atrogin-1, MuRF1 and LC3 genes. Extensor digitorum longus muscles and C2C12 myotubes exhibited a reduction in protein turnover. Cardiomyocytes showed an increase in proteolysis by activating autophagy and the ubiquitin proteasome... Tipo: Info:eu-repo/semantics/article Palavras-chave: Myostatin; Skeletal muscle; Cardiomyocytes; Protein degradation; Protein synthesis. Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017001200604 Registros recuperados: 1 Primeira ... 1 ... Última

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