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In vitro Fluoride Release and Tensile Bond Strength of a Polymeric Intra-Buccal Bioadhesive International Journal of Morphology
Pedrazzi,Vinícius; Lara,Elza Helena Guimarães; Panzeri,Heitor; Collett,John H; Issa,João Paulo Mardegan.
The intra-buccal polymeric bioadhesive systems that can stay adhered to the oral soft tissues for drug programmed release, with the preventive and/or therapeutic purpose has been employed for large clinical situations. A system based on hydroxypropyl methyl cellulose/Carbopol 934'/magnesium stearate (HPMC/Cp/StMg) was developed having the sodium fluoride as active principle. This kind of system was evaluated according to its resistance to the removal by means of physical test of tensile strength. Swine buccal mucosa extracted immediately after animals' sacrifice was employed as substrate for the physical trials, to obtain 16 test bodies. Artificial saliva with or without mucin was used to involve the substrate/bioadhesive system sets during the trials....
Tipo: Journal article Palavras-chave: Drug delivery systems; Oral delivery; Mucin; Oral mucosa; Fluoride.
Ano: 2009 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000300026
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Evaluation of Some Biological Aspects of the Presence of Abrasive Silica and Thickening Silica  in Basic Formulations of Dentifrices International Journal of Morphology
Pedrazzi,Vinícius; Del Ciampo,José Orestes; do Nascimento,Cássio; Issa,João Paulo Mardegan.
The aim of this study was to evaluate some biological characteristics and toxicity of basic formulations of dentifrices containing such substances, and to compare them with two existing products in market which also contains silic in their formulations. In this way, it was evaluated some biological parameters: weight of the animals, oral toxicity, hematological parameters, urinary analysis, and histological evaluation. The thrombocytes were also statistically at normal levels. The glutamate-pyruvate transaminase (TGP) showed normal aspect in 5 of the tested groups, as in control. Meanwhile, the oxalacetic transaminase (AST) in one group had a small increase in the control group. Regarding urine, in exception the rats of one group, the rats of the 4 other...
Tipo: Journal article Palavras-chave: Silica; Dentifrices; Histology; Wistar rats.
Ano: 2009 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000100028
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