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| Fiers, M.W.E.J.; Kleter, G.A.; Peijnenburg, A.A.C.M.; Nijland, H.; Nap, J.P.; Van Ham, R.C.H.J.. |
| AllermatchTM (http://allermatch.org) is a novel web tool for the efficient and standardized prediction of potential allergenicity of proteins according to the current recommendations of the FAO/WHO Expert Consultation, as outlined in the Codex alimentarius. A query amino-acid sequence is compared against the Allermatch- Allergen database based on current SwissProt and WHO-IUIS allergen lists. The web tool uses a sliding window to identify stretches of 80 amino acids with more than 35% similarity, or identical small stretches of at least six amino acids. The outcome of the analyses is presented in a concise format. AllermatchTM is likely to contribute to improved, transparent and more consistent analyses of potential allergenicity of genetically modified... |
| Tipo: Conference proceedings |
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| Ano: 2005 |
URL: http://library.wur.nl/ojs/index.php/frontis/article/view/1068 |
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| Kleter, G.A.; Peijnenburg, A.A.C.M.. |
| The potential allergenicity of novel proteins expressed in genetically modified organisms is an important item in the safety assessment of these organisms. The various components of the allergenicity assessment include the source of the protein, sequence similarity with known allergenic proteins, in vitro digestibility, sera binding tests, animal models and clinical tests. Recent developments in the field of bioinformatics studies on the sequence similarity of novel proteins with allergenic proteins, as well as in vitro digestibility, are discussed. |
| Tipo: Conference proceedings |
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| Ano: 2005 |
URL: http://library.wur.nl/ojs/index.php/frontis/article/view/1066 |
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