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The T-cell anergy induced by Leishmania amazonensis antigens is related with defective antigen presentation and apoptosis Anais da ABC (AABC)
Pinheiro,Roberta O.; Pinto,Eduardo F.; Benedito,Alessandra B.; Lopes,Ulisses G.; Rossi-Bergmann,Bartira.
Leishmania amazonensis is the main agent of diffuse cutaneous leishmaniasis, a disease associated with anergic immune responses. In this study we show that the crude antigen of Leishmania amazonensis (LaAg) but not L. braziliensis promastigotes (LbAg) contains substances that suppress mitogenic and spontaneous proliferative responses of T cells. The suppressive substances in LaAg are thermoresistant (100ºC/1h) and partially dependent on protease activity. T cell anergy was not due to a decreased production of growth factors as it was not reverted by addition of exogenous IL-2, IL-4, IFN-gamma or IL-12. LaAg did not inhibit anti-CD3-induced T cell activation, suggesting that anergy was due to a defect in antigen presentation. It was also not due to cell...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Leishmania; Anergy; Apoptosis.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652004000300006
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