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| Prajakta Belsare; Milind Watve. |
| We examine here, using a simple mathematical model, the conditions under which thrifty genes or fetal programming could evolve. Obesity and related disorders are thought to have their roots in metabolic thirftiness that evolved to combat periodic starvation. The failure to detect any thrifty genes and the association of low birth weight with type 2 diabetes, caused a shift in the concept from thrifty gene to thrifty phenotype and fetal programming. This hypothesis assumes that intra-uterine undernutrition programs the body to be thrifty, predicting and preparing for starvation in later life. However, there are reproductive costs associated with thriftiness. Results of the model suggest that under no condition thrifty and non-thrifty genes would co-exist... |
| Tipo: Poster |
Palavras-chave: Developmental Biology; Evolutionary Biology. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/2709/version/1 |
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| Milind Watve; Maithili Jog; Prajakta Belsare. |
| The metabolic syndrome disorders (MSD) including type 2 diabetes, hypertension, hypercholesterolemia, atherosclerosis and cardiovascular disease are known to be triggered by lifestyle change. We state and support a hypothesis here that changes in behavior rather than changes in diet and metabolism are central to MSD. We provide and discuss evidence in support of the following sequence of arguments. (i) Diet, thriftiness and obesity centered paradigm is inadequate to explain most of the physiological and immunological changes associated with metabolic syndrome disorders (MSD). (ii) Comparative studies show that relative obesity rather than absolute obesity is strongly associated with various parameters of MSD and further perception of calories without... |
| Tipo: Presentation |
Palavras-chave: Neuroscience. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/4833/version/1 |
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| Milind Watve; Sonam Mandani; Prajakta Belsare. |
| The adipose tissue is an active endocrine organ which secretes proinflammatory cytokines and chemokines resulting into raised serum levels. Hypercytokinemia has been interpreted as raised level of innate immunity and its evolution is interpreted as a response to increased chances of infection under starvation conditions in which the thrifty phenotype evolved. If starvation and infection challenges co-occurred during hunter gatherer life, thrifty genotype and infection resistant genotype may have co-evolved. An inherent weakness of this explanation is that in obesity or insulin resistance there is no evidence of increased resistance to infections. The raised levels of inflammatory cytokines have not been demonstrated to combat infections or enhance wound... |
| Tipo: Poster |
Palavras-chave: Ecology; Immunology. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/2710/version/1 |
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| Milind G. Watve; Samit Watve; Prajakta Belsare; Uttara Lele; Snehal Bari; Sarika Karande. |
| Aging is one of the most intriguing processes of biology and despite decades of research, many aspects of aging are poorly understood. Aging is known to occur in bacteria and yeast that divide with morphological asymmetry. Morphologically symmetrically dividing bacteria such as _Escherichia coli_ were assumed not to age until they were shown to divide with functional asymmetry leading to aging and death of some of the cells even in exponentially growing cultures. In asymmetrically dividing _E. coli_ the newly synthesized components are presumed to occupy one pole so that after division one of the daughter cells receives newly synthesized components whereas the other retains the older components. Mathematical models predicted that at the population level,... |
| Tipo: Manuscript |
Palavras-chave: Microbiology. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/2071/version/1 |
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| Manasee Mankar; Radhika Joshi; Prajakta Belsare; Maithili Jog; Milind Watve. |
| Fat accumulation has been classically considered as a means of energy storage. Obese people are theorized as metabolically ‘thrifty’, saving energy during times of food abundance. However, recent research has highlighted many neuro-behavioral and social aspects of obesity, with a suggestion that obesity, abdominal obesity in particular, may have evolved as a social signal. We tested here whether body proportions, and abdominal obesity in particular, are perceived as signals revealing personality traits. 

Faceless drawings of three male body forms namely lean, muscular and feminine, each with and without abdominal obesity were shown in a randomized order to a group of 222 respondents. A list of 30... |
| Tipo: Poster |
Palavras-chave: Ecology. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/2711/version/1 |
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