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Gene polymorphism of interleukin 1 and 8 in chronic gastritis patients infected withHelicobacter pylori J. Venom. Anim. Toxins incl. Trop. Dis.
Caleman Neto,Agostinho; Rasmussen,Lucas T; Labio,Roger W de; Queiroz,Valdeir F de; Smith,Marília de AC; Viani,Gustavo A; Payão,Spencer LM.
Background : Epidemiological investigations have indicated thatHelicobacter pyloriinduces inflammation in the gastric mucosa regulated by several interleukins. The genesIL1BandIL8are suggested as key factors in determining the risk of gastritis. The aim of this paper was to evaluate the association of gene polymorphism of interleukin-1 and interleukin-8 with chronic gastrits inH. pyloriinfected patients. A total of 60 patients underwent endoscopic procedure. Biopsy samples were collected for urease test, histopathological and molecular exams. The DNA of theses samples was extracted for detection ofH. pyloriand analysis of the genes mentioned above. Patients with gastritis had a higher frequency ofH. pylori-positive samples.Results : H. pyloriwas detected...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Helicobacter pylori; Polymorphism; Interleukin.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992014000200327
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