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	Provedor de dados Anais da ABC (AABC) (2) Autor MACHADO,RICARDO C. (2) RAMOS,RICARDO GUELERMAN P. (2) COSTA,MARA S.A. (1) MODA,LIVIA (1) PEREIRA,RODRIGO N.R. (1) Palavra-chave Drosophila (2) Cell adhesion (1) Cell death (1) Glutamine-rich repeats (1) Immunoglobulin superfamily (1) Rst-irreC (1) Transgenic organisms (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2002 (1) 2000 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Ubiquitous overexpression of a transgene encoding the extracellular portion of the Drosophila Roughest-Irregular Chiasm C protein induces early embryonic lethality Anais da ABC (AABC) MODA,LIVIA; MACHADO,RICARDO C.; RAMOS,RICARDO GUELERMAN P.. The cell adhesion molecule Rst-irreC is a transmembrane glycoprotein of the immunoglobulin superfamily involved in several important developmental processes in Drosophila, including axonal pathfinding in the optic lobe and programmed cell death and pigment cell differentiation in the pupal retina. As an initial step towards the "in vivo'' functional analysis of this protein we have generated transgenic fly stocks carrying a truncated cDNA construct encoding only the extracellular domain of Rst-IrreC under the transcriptional control of the heat shock inducible promoter hsp70. We show that heat-shocking embryos bearing the transgene during the first 8hs of development lead to a 3-4 fold reduction in their viability compared to wild type controls. The... Tipo: Info:eu-repo/semantics/article Palavras-chave: Drosophila; Transgenic organisms; Cell adhesion; Immunoglobulin superfamily. Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652000000300011 "In vivo" toxicity of a truncated version of the Drosophila Rst-IrreC protein is dependent on the presence of a glutamine-rich region in its intracellular domain Anais da ABC (AABC) MACHADO,RICARDO C.; PEREIRA,RODRIGO N.R.; COSTA,MARA S.A.; RAMOS,RICARDO GUELERMAN P.. The roughest-irregular chiasm C ( rst-irreC) gene of Drosophila melanogaster encodes a transmembrane glycoprotein containing five immunoglobulin-like domains in its extracellular portion and an intracytoplasmic tail rich in serine and threonine as well some conserved motifs suggesting signal transduction activity. In the compound eye, loss-of-function rst-irreC mutants lack the characteristic wave of programmed cell death happening in early pupa and which is essential for the elimination of the surplus interommatidial cells. Here we report an investigation on the role played by the Rst-irreC molecule in triggering programmed cell death. "In vivo" transient expression assays showed that deletion of the last 80 amino acids of the carboxyl terminus produces a... Tipo: Info:eu-repo/semantics/article Palavras-chave: Drosophila; Rst-irreC; Glutamine-rich repeats; Cell death. Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652002000200007 Registros recuperados: 2 Primeira ... 1 ... Última

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