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| Dinakaran,Sathis Kumar; Kumar,Santhos; Banji,David; Avasarala,Harani; Rao,Venkateshwar. |
| The purpose of this research study was to establish ziprasidone HCl NR 40 mg and trihexyphenidyl HCl SR 4mg in the form of bi-layer sustained release floating tablets. The tablets were prepared using sodium HPMC K4M / HPMC K15M as bio-adhesive polymers and sodium bicarbonate acting as a floating layer. Tablets were evaluated based on different parameters such as thickness, hardness, friability, weight variation, in vitro dissolution studies, content of active ingredient and IR studies. The physico-chemical properties of the finished product complied with the specifications. In vitro release from the formulation was studied as per the USP XXIII dissolution procedure. The formulations gave a normal release effect followed by sustained release for 12 h which... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Bi-layer tablet; Ziprasidone HCl; Trihexyphenidyl HCl; Sustained release. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000300012 |
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