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| Reis,A.F.; Miranda,W.L.; Chacra,A.R.. |
| Low levels of sex hormone-binding globulin (SHBG) are considered to be an indirect index of hyperinsulinemia, predicting the later onset of diabetes mellitus type 2. In the insulin resistance state and in the presence of an increased pancreatic ß-cell demand (e.g. obesity) both absolute and relative increases in proinsulin secretion occur. In the present study we investigated the correlation between SHBG and pancreatic ß-cell secretion in men with different body compositions. Eighteen young men (30.0 ± 2.4 years) with normal glucose tolerance and body mass indexes (BMI) ranging from 22.6 to 43.2 kg/m2 were submitted to an oral glucose tolerance test (75 g) and baseline and 120-min blood samples were used to determine insulin, proinsulin and C-peptide by... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Insulin; Proinsulin; Sex hormone-binding globulin; Obesity. |
| Ano: 1998 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998001200006 |
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| Ramalho,A.C.; Lazaretti-Castro,M.; Hauache,O.; Kasamatsu,T.; Brandão,C.; Reis,A.F.; Takata,E.; Cafalli,F.; Tavares,F.; Gimeno,S.G.A.; Vieira,J.G.H.. |
| Fractures are the feared consequences of osteoporosis and fractures of the proximal femur (FPF) are those that involve the highest morbidity and mortality. Thus far, evaluation of bone mineral density (BMD) is the best way to determine the risk of fracture. Genetic inheritance, in turn, is one of the major determinants of BMD. A correlation between different genotypes of the vitamin D receptor (VDR) and BMD has been recently reported. On this basis, we decided to determine the importance of the determination of VDR genotype in the presence of an osteoporotic FPF in a Brazilian population. We studied three groups: group I consisted of 73 elderly subjects older than 65 years (78.5 ± 7.2 years) hospitalized for nonpathological FPF; group II consisted of 50... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Osteoporosis; Fracture of proximal femur (FPF); Vitamin D receptor polymorphism. |
| Ano: 1998 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000700006 |
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